Home Microbiology SARS-CoV inhibitor - COVID-19 inhibitor - DNA/RNA Synthesis inhibitor VV116 For research use only.

VV116

Synonyms: JT001

VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.

VV116 Chemical Structure

VV116 Chemical Structure

CAS No. 2647442-33-7(free base)

Purity & Quality Control

Batch: E111101 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 98.95%
98.95

VV116 Related Products

Biological Activity

Description VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.
Targets
RdRp [1]
0.67 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06093230 Completed
Subjects With Liver Function Injury|Normal Liver Function Subject
Shanghai Vinnerna Biosciences Co. Ltd.|Sponsor GmbH
 July 28 2023 Phase 1
NCT06093308 Completed
Elderly Subjects With Underlying Diseases
Shanghai Vinnerna Biosciences Co. Ltd.|Sponsor GmbH
 July 12 2023 Phase 1
NCT05895812 Completed
Subjects With Renal Impairment|Healthy Subjects
Shanghai Vinnerna Biosciences Co. Ltd.|Sponsor GmbH
 May 8 2023 Phase 1
NCT05582629 Completed
Mild to Moderate COVID-19
Shanghai Vinnerna Biosciences Co. Ltd.|Sponsor GmbH
 October 21 2022 Phase 3
NCT05221138 Completed
Healthy Subjects
Vigonvita Life Sciences
 December 30 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 502.54 Formula

C24H30DN5O7
CAS No. 2647442-33-7(free base) SDF --
Smiles CC(C)C(=O)OCC1OC(C#N)(C(OC(=O)C(C)C)C1OC(=O)C(C)C)C2=CC(=C3[N]2N=CN=C3N)[2H]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (198.98 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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