Home Microbiology SARS-CoV inhibitor - COVID-19 inhibitor EIDD-1931 (NHC) For research use only.

EIDD-1931 (NHC)

Synonyms: Beta-d-N4-hydroxycytidine

EIDD-1931 (NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. EIDD-1931 (NHC) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.

EIDD-1931 (NHC) Chemical Structure

EIDD-1931 (NHC) Chemical Structure

CAS No. 3258-02-4

Purity & Quality Control

Batch: S083301 Water]15 mg/mL]false]Ethanol]3 mg/mL]false]]]false Purity: 99.73%
99.73

EIDD-1931 (NHC) Related Products

Biological Activity

Description EIDD-1931 (NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. EIDD-1931 (NHC) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05386758 Completed
Renal Impairment
Merck Sharp & Dohme LLC
 June 29 2022 Phase 1
NCT05386589 Completed
Hepatic Impairment
Merck Sharp & Dohme LLC
 June 14 2022 Phase 1
NCT05061472 Active not recruiting
Contraceptive Usage|Overweight or Obesity|Body Weight Changes|Appetitive Behavior|Eating Behavior
University of Colorado Denver
 May 23 2022 --

Chemical Information & Solubility

Molecular Weight 259.22 Formula

C9H13N3O6
CAS No. 3258-02-4 SDF --
Smiles OCC1OC(C(O)C1O)N2C=C\C(NC2=O)=N\O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 15 mg/mL

Ethanol : 3 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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