Home DNA Damage/DNA Repair Nucleoside Analog/Antimetabolite chemical - DNA/RNA Synthesis inhibitor - Influenza Virus inhibitor Triazavirin (TZV) For research use only.

Triazavirin (TZV)

Synonyms: Riamilovir

Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.

Triazavirin (TZV) Chemical Structure

Triazavirin (TZV) Chemical Structure

CAS No. 928659-17-0

Purity & Quality Control

Batch: S685401 DMSO]57 mg/mL]false]Water]20 mg/mL]false]Ethanol]Insoluble]false Purity: 99.19%
99.19

Triazavirin (TZV) Related Products

Biological Activity

Description Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04581915 Terminated
Covid19
Wits Health Consortium (Pty) Ltd|PharmaCentrix (Pty) Ltd|Perinatal HIV Research Unit of the University of the Witswatersrand
 September 8 2020 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 286.2 Formula

C5H7N6NaO5S
CAS No. 928659-17-0 SDF --
Smiles CSC1=NN2C(=C(N=NC2=N1)[N+](=O)[O-])[O-].O.O.[Na+]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 57 mg/mL ( (199.16 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 20 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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