S7273 |
SC75741
|
SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation. |
-
J Transl Med, 2024, 22(1):672
-
World J Stem Cells, 2024, 16(5):575-590
-
J Exp Clin Cancer Res, 2023, 42(1):25
|
|
S1848 |
Curcumin
|
Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on. |
-
Cancer Cell Int, 2024, 24(1):303
-
Front Pharmacol, 2024, 15:1418902
-
PLoS Negl Trop Dis, 2024, 18(8):e0012428
|
|
S7975 |
Favipiravir (T-705)
|
Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
|
-
J Med Virol, 2024, 96(1):e29372
-
Okayama University, 2023 , 10.18926/65391
-
Nat Commun, 2022, 13(1):2256
|
|
S1627 |
Nitazoxanide
|
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
-
Nat Commun, 2024, 15(1):8708
-
Mol Ther, 2024, S1525-0016(24)00340-X
-
Biomed Pharmacother, 2024, 171:116195
|
|
S2597 |
Oseltamivir Phosphate
|
Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza. |
-
Clin Immunol, 2024, 262:110178
-
Front Immunol, 2023, 14:1155880
-
iScience, 2022, 25(4):104088
|
|
S3007 |
Zanamivir
|
Zanamivir (GG167,GR 121167X) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus. |
-
Front Immunol, 2019, 10:2575
-
Emerg Microbes Infect, 2014, 3(11):e78
-
Emerg Microbes Infec, 2014, 3, e78
|
|
S2716 |
Peramivir Trihydrate
|
Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. |
-
Viruses, 2024, 16(9)1467
-
Emerg Microbes Infect, 2014, 3(11):e78
-
Emerg Microbes Infec, 2014, 3, e78
|
|
S2120 |
Arbidol HCl
|
Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections. |
-
mBio, 2024, e0228723.
-
PLoS One, 2022, 17(11):e0276751
|
|
S1964 |
Rimantadine
|
Rimantadine (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM. |
-
J Virol Methods, 2019, 274:113714
|
|
S0289 |
KIN1148
|
KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. KIN1148 is an influenza vaccine adjuvant that enhances flu vaccine efficacy. |
-
J Allergy Clin Immunol, 2022, S0091-6749(22)01423-3
|
|
S0433 |
Nucleozin
|
Nucleozin is an antivirus agent that targets influenza A nucleoprotein (NP). Nucleozin triggers the aggregation of NP and inhibits its nuclear accumulation. |
-
Nat Commun, 2022, 13(1):2079
|
|
S6854 |
Triazavirin (TZV)
|
Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza. |
-
Nature, 2022, 604(7904):120-126
|
|
S0861 |
Laninamivir Octanoate
|
Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity. |
|
|
S5499 |
Amantadine
|
Amantadine (1-Adamantanamine) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.Amantadine can relieve muscle stiffness, tremors, and movement disorders caused by Parkinson's disease. |
|
|
E3128 |
Isatidis Folium Extract
|
Isatidis Folium Extract is obtained from the dry leaves of Isatis indigotica Fort. (family Cruciferae), has been commonly applied in orient countries for centuries as antipyretic, antiviral, anti-inflammatory, anti-influenza, and anti-cancer agents. |
|
|
S3897 |
(-)-Arctigenin
|
(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer. |
|
|
E0207 |
Chebulinic acid
|
Chebulinic acid, a phenolic compound isolated from Terminalia chebula fruit, is a novel Influenza viral neuraminidase inhibitor. Chebulinic acid is a antiangiogenic agent through inhibiting the actions of VEGF. Chebulinic acid shows antitumour activity.
|
|
|
S2869 |
Adamantane
|
Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.
|
|
|
S3870 |
D-Pinitol
|
D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant. |
|
|
S4491 |
Cetylpyridinium chloride monohydrate
|
Cetylpyridinium chloride (CPC, Hexadecylpyridinium chloride) monohydrate is a broad-spectrum antimicrobial agent that possesses virucidal activity against susceptible and resistant strains of influenza virus by targeting and disrupting the viral envelope. |
|
|
S7273 |
SC75741
|
SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation. |
- J Transl Med, 2024, 22(1):672
- World J Stem Cells, 2024, 16(5):575-590
- J Exp Clin Cancer Res, 2023, 42(1):25
|
|
S1848 |
Curcumin
|
Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on. |
- Cancer Cell Int, 2024, 24(1):303
- Front Pharmacol, 2024, 15:1418902
- PLoS Negl Trop Dis, 2024, 18(8):e0012428
|
|
S7975 |
Favipiravir (T-705)
|
Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
|
- J Med Virol, 2024, 96(1):e29372
- Okayama University, 2023 , 10.18926/65391
- Nat Commun, 2022, 13(1):2256
|
|
S1627 |
Nitazoxanide
|
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
- Nat Commun, 2024, 15(1):8708
- Mol Ther, 2024, S1525-0016(24)00340-X
- Biomed Pharmacother, 2024, 171:116195
|
|
S2597 |
Oseltamivir Phosphate
|
Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza. |
- Clin Immunol, 2024, 262:110178
- Front Immunol, 2023, 14:1155880
- iScience, 2022, 25(4):104088
|
|
S3007 |
Zanamivir
|
Zanamivir (GG167,GR 121167X) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus. |
- Front Immunol, 2019, 10:2575
- Emerg Microbes Infect, 2014, 3(11):e78
- Emerg Microbes Infec, 2014, 3, e78
|
|
S2716 |
Peramivir Trihydrate
|
Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. |
- Viruses, 2024, 16(9)1467
- Emerg Microbes Infect, 2014, 3(11):e78
- Emerg Microbes Infec, 2014, 3, e78
|
|
S2120 |
Arbidol HCl
|
Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections. |
- mBio, 2024, e0228723.
- PLoS One, 2022, 17(11):e0276751
|
|
S1964 |
Rimantadine
|
Rimantadine (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM. |
- J Virol Methods, 2019, 274:113714
|
|
S0289 |
KIN1148
|
KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. KIN1148 is an influenza vaccine adjuvant that enhances flu vaccine efficacy. |
- J Allergy Clin Immunol, 2022, S0091-6749(22)01423-3
|
|
S0433 |
Nucleozin
|
Nucleozin is an antivirus agent that targets influenza A nucleoprotein (NP). Nucleozin triggers the aggregation of NP and inhibits its nuclear accumulation. |
- Nat Commun, 2022, 13(1):2079
|
|
S6854 |
Triazavirin (TZV)
|
Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza. |
- Nature, 2022, 604(7904):120-126
|
|
S0861 |
Laninamivir Octanoate
|
Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity. |
|
|
S5499 |
Amantadine
|
Amantadine (1-Adamantanamine) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.Amantadine can relieve muscle stiffness, tremors, and movement disorders caused by Parkinson's disease. |
|
|
E3128 |
Isatidis Folium Extract
|
Isatidis Folium Extract is obtained from the dry leaves of Isatis indigotica Fort. (family Cruciferae), has been commonly applied in orient countries for centuries as antipyretic, antiviral, anti-inflammatory, anti-influenza, and anti-cancer agents. |
|
|
E0207 |
Chebulinic acid
|
Chebulinic acid, a phenolic compound isolated from Terminalia chebula fruit, is a novel Influenza viral neuraminidase inhibitor. Chebulinic acid is a antiangiogenic agent through inhibiting the actions of VEGF. Chebulinic acid shows antitumour activity.
|
|
|
S2869 |
Adamantane
|
Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.
|
|
|
S4491 |
Cetylpyridinium chloride monohydrate
|
Cetylpyridinium chloride (CPC, Hexadecylpyridinium chloride) monohydrate is a broad-spectrum antimicrobial agent that possesses virucidal activity against susceptible and resistant strains of influenza virus by targeting and disrupting the viral envelope. |
|
|