Home Microbiology Influenza Virus chemical (-)-Arctigenin For research use only.

(-)-Arctigenin

(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.

(-)-Arctigenin Chemical Structure

(-)-Arctigenin Chemical Structure

CAS No. 7770-78-7

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(-)-Arctigenin Related Products

Biological Activity

Description (-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.
In vitro
In vitro Arctigenin induces apoptosis in HT-29 colon cancer cells by regulating ROS and p38 MAPK pathways[1]. It is a phytoestrogen that exerts a proliferative effect by binding to the ER. Treatment with arctigenin effectively downregulates ERα expression. Thus, arctigenin, mainly targets the mTOR pathway in ERα-positive MCF-7 human breast cancer cells, leading to autophagy-induced cell death and the downregulation of ERα expression[2]. Arctigenin decreases BACE1 translation via dephosphorylation of eIF2α, causing the suppression of Aβ production, and initiates autophagy through both AMPK/Raptor signaling activation and AKT/mTOR pathway inhibition, resulting in enhanced Aβ clearance. Arctigenin suppresses BACE1 activity via inhibition of BACE1 translation[3].
Cell Research Cell lines HEK293-APPswe, primary cortical neuronal, and BV2 cells
Concentrations 0.1, 1, 10, 20, 40 μM
Incubation Time 24 h
Method Cells are treated with 0.1% DMSO or different concentrations of arctigenin for 24 h. The cell culture media are collected, and a complete protease inhibitor mixture is added. The culture media are then centrifuged by 20,000 × g at 4°C for 30 min, and supernatants are collected.
In Vivo
In vivo Treatment of arctigenin in mice highly decreases Aβ formation and senile plaques and efficiently ameliorates AD mouse memory impairment of APP/PS1 transgenic model mice[3].
Animal Research Animal Models The APP/PS1 mice
Dosages 3 mg/kg/d
Administration i.p.

Chemical Information & Solubility

Molecular Weight 372.41 Formula

C21H24O6
CAS No. 7770-78-7 SDF --
Smiles COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 74 mg/mL ( (198.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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