Home Microbiology Neuraminidase inhibitor - Influenza Virus inhibitor Oseltamivir Phosphate For research use only.

Oseltamivir Phosphate

Synonyms: Tamiflu

Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.

Oseltamivir Phosphate Chemical Structure

Oseltamivir Phosphate Chemical Structure

CAS No. 204255-11-8

Purity & Quality Control

Oseltamivir Phosphate Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK cells Function assay 36 h Antiinfluenza activity against influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs, IC50=1.1 μM 22341943
Click to View More Cell Line Experimental Data

Biological Activity

Description Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.
Targets
Neuraminidase [1]
In vitro
In vitro

Oseltamivir Phosphate, anti-Neu1 antibodies, and matrix metalloproteinase-9-specific inhibitor blocks Neu1 activity associated with EGF-stimulated TNBC MDA-MB-231 cells[2]. Oseltamivir slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.
Cell Research Cell lines MDA-MB-231 cells/MCF-7 cells
Concentrations 500, 600, 700, 800 μg/mL
Incubation Time 24, 48, and 72 h 
Method

Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.
In Vivo
In vivo

Oseltamivir Phosphate monotherapy may be the effective treatment therapy for TNBC(Triple-negative breast cancers)[2]. It is efficacious in treating infections caused by H5N1 and H9N2 influenza viruses in mice[3]. After dosing, the prodrug (Oseltamivir phosphate) is readily absorbed from the gastrointestinal tract and rapidly converted into the active metabolite, OC. In all patient groups, OC has high bioavailability and is systemically distributed to infection sites at concentrations sufficient to inhibit a range of influenza virus neuraminidases[4].
Animal Research Animal Models RAGxCγ double mutant mouse
Dosages 30 or 50 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05375864 Not yet recruiting
Severe Influenza
Assistance Publique - Hôpitaux de Paris
 December 1 2022 Not Applicable
NCT02507648 Completed
Healthy
Genuine Research Center Egypt|Pharmacare PLC Palestine
 March 2013 Phase 1
NCT01690637 Terminated
Influenza|Human Influenza
Centers for Disease Control and Prevention|Universidad del Valle Guatemala|Hospital Nacional San Juan de Dios de Santa Ana El Salvador|Hospital Nacional San Juan de Dios de San Miguel El Salvador|Hospital Del Nino Panama|Hospital de Especialidades Pediátricas Omar Torrijos Herrera Panama|Hospital Jose Domingo de Obaldia Panama
 September 2012 Phase 4
NCT01443806 Completed
Metabolic Disease
University of Oxford|South East Asia Infectious Disease Clinical Research Network
 July 2011 Phase 4

Chemical Information & Solubility

Molecular Weight 410.4 Formula

C16H28N2O4.H3PO4
CAS No. 204255-11-8 SDF Download Oseltamivir Phosphate SDF
Smiles CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (199.8 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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