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Nucleoside Analog/Antimetabolite

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group
Cat.No. Product Name Information Product Use Citations Product Validations
S1200 Decitabine Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
Cancer Cell, 2025, S1535-6108(25)00223-5
Nat Commun, 2025, 16(1):4451
Cell Rep Med, 2025, S2666-3791(25)00102-8
Verified customer review of Decitabine
S1782 5-Azacytidine (5-Aza, Azacitidine) Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.
Mol Cancer, 2025, 24(1):154
Cell Rep Med, 2025, S2666-3791(25)00102-8
Cell Rep Med, 2025, 6(12):102461
Verified customer review of 5-Azacytidine (5-Aza, Azacitidine)
S1149 Gemcitabine Hydrochloride Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy.
Cancer Cell, 2025, S1535-6108(25)00271-5
Nat Cell Biol, 2025, 27(6):1021-1034
Trends Biotechnol, 2025, S0167-7799(25)00406-8
Verified customer review of Gemcitabine Hydrochloride
S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Cell Stem Cell, 2025, S1934-5909(25)00265-6
Verified customer review of 5-Fluorouracil (5-FU)
S1714 Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Nature, 2025, 10.1038/s41586-025-08974-4
Cell, 2025, S0092-8674(25)00556-2
Cancer Cell, 2025, 43(8):1530-1548.e9
Verified customer review of Gemcitabine
S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Nat Commun, 2025, 16(1):4133
Acta Pharm Sin B, 2025, 15(10):5277-5293
Cell Death Dis, 2025, 16(1):601
Verified customer review of Cytarabine
S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Cell Mol Immunol, 2025, 22(11):1478-1490
J Immunother Cancer, 2025, 13(7)e010926
Cell Rep, 2025, 44(4):115559
Verified customer review of Fludarabine
S2053 Cytidine Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.
Nat Commun, 2025, 16(1):4451
Virology, 2025, 610:110598
Cancer Res, 2022, canres.1707.2021
S2439 Guanosine Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
Nat Commun, 2022, 13(1):5845
Cancer Res, 2022, canres.1707.2021
Nat Commun, 2020, 11(1):6339
S3702 Dihydrothymine Dihydrothymine is an intermediate breakdown product of thymine.
Cell Death Differ, 2019, 26(11):2223-2236