Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor - RNR inhibitor Osalmid For research use only.

Osalmid

Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

Osalmid Chemical Structure

Osalmid Chemical Structure

CAS No. 526-18-1

Purity & Quality Control

Osalmid Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Biological Activity

Description Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
Targets
RRM2 [1]
(Cell-free assay)
8.23 μM
In vitro
In vitro

Osalmid is shown to be 10-fold more active in inhibiting RR activity, and significantly inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid significantly inhibits HBV DNA replication in a time- and dose-dependent manner[1].
Cell Research Cell lines HepG2.2.15 cells
Concentrations 0, 400, 600, 900, 1200 μM
Incubation Time 36 h
Method

Cells are treated with various concentrations of osalmid for 36 h.
In Vivo
In vivo

Osalmid significantly reduces RR activity and HBV DNA replication in vivo[1].
Animal Research Animal Models BALB/c mice
Dosages 400 mg/kg
Administration oral gavage

Chemical Information & Solubility

Molecular Weight 229.23 Formula

C13H11NO3
CAS No. 526-18-1 SDF Download Osalmid SDF
Smiles C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 45 mg/mL ( (196.3 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 45 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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