Home DNA Damage/DNA Repair DNA/RNA Synthesis chemical Azaguanine-8 For research use only.

Azaguanine-8

Synonyms: NSC-749, SF-337, SK 1150

Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.

Azaguanine-8 Chemical Structure

Azaguanine-8 Chemical Structure

CAS No. 134-58-7

Purity & Quality Control

Azaguanine-8 Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H.Ep cells Cytotoxicity assay Cytotoxicity against H.Ep cells, IC50=2 μM 6620307
Click to View More Cell Line Experimental Data

Biological Activity

Description Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.
In vitro
In vitro 8-Azaguanine is a purine analogue that shows antineoplastic activity. It functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.
Experimental Result Images Methods Biomarkers Images PMID
Western blot Ac-H3 26668215
Growth inhibition assay Cell viability 30804405
In Vivo
In vivo A study of the in vivo metabolism of 8-azaguanine-2-C 14 by mouse neoplasms that are susceptible or resistant to growth inhibition by 8-azagnanine have been reported. The results show that the growth of those neoplasms which convert significant amounts of 8-azaguanine to 8-azaguanylic acid is inhibited by 8-azaguanine.

Chemical Information & Solubility

Molecular Weight 152.11 Formula

C4H4N6O
CAS No. 134-58-7 SDF Download Azaguanine-8 SDF
Smiles C12=NNN=C1N=C(NC2=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 4 mg/mL ( (26.29 mM) Warmed with 50°C water bath; Ultrasonicated; Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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