Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Cyclocytidine HCl For research use only.

Cyclocytidine HCl

Synonyms: NSC 145668 HCl

Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.

Cyclocytidine HCl Chemical Structure

Cyclocytidine HCl Chemical Structure

CAS No. 10212-25-6

Purity & Quality Control

Cyclocytidine HCl Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Biological Activity

Description Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
In vitro
In vitro Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. [1]
In Vivo
In vivo Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. [2]Cyclocytidine provides treatment for leukemia. [3]
Animal Research Animal Models BDF1 mice inoculated L1210 cells
Dosages 20 or 100 mg/kg/day
Administration i.p. or s.c.

Chemical Information & Solubility

Molecular Weight 261.66 Formula

C9H12ClN3O4
CAS No. 10212-25-6 SDF Download Cyclocytidine HCl SDF
Smiles C1=CN2C3C(C(C(O3)CO)O)OC2=NC1=N.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 52 mg/mL

DMSO : 10 mg/mL ( (38.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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