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Technical Data
| Formula | C9H12ClN3O4 |
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| Molecular Weight | 261.66 | CAS No. | 10212-25-6 | |
| Solubility (25°C)* | In vitro | Water | 52 mg/mL (198.73 mM) | |
| DMSO | 10 mg/mL (38.21 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
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| In vitro | Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. [1] |
| In vivo | Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. [2]Cyclocytidine provides treatment for leukemia. [3] |
Protocol (from reference)
| Animal Study:[2] |
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References
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Selleck's Cyclocytidine HCl has been cited by 5 publications
| Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] | PubMed: 37354638 |
| Cyclocytidine hydrochloride inhibits the synthesis of relaxed circular DNA of hepatitis B virus [ PeerJ, 2022, 10:e13719] | PubMed: 35846878 |
| Inhibitory effect of cyclocytidine hydrochloride on vesicular stomatitis virus infection. [ Acta Biochim Biophys Sin (Shanghai), 2020, 14 pii: gmaa017] | PubMed: 32289151 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| Yeast-Based Screen to Identify Natural Compounds with a Potential Therapeutic Effect in Hailey-Hailey Disease. [ Int J Mol Sci, 2018, 19(6)] | PubMed: 29925776 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.