RNR

RNR Products

All (5)
RNR Inhibitors (5)
New RNR Products

Catalog No.	Product Name	Information	Product Use Citations
S1218	Clofarabine	Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.	Front Oncol, 2023, 13:1287444 Cancer Res, 2022, 82(4):721-733 Clin Transl Med, 2022, 12(2):e747
S7470	Triapine (3-AP)	Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.	J Virol, 2023, 97(8):e0026723 Res Sq, 2023, rs.3.rs-3126261 Cancer Res, 2022, 82(4):721-733
S0283	COH-29	COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.	Adv Sci (Weinh), 2021, e2100881
S3385	NSAH	NSAH (HNASH) is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.	Pharmaceutics, 2022, 14-71387
S3641	Osalmid	Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
S1218	Clofarabine	Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.	Front Oncol, 2023, 13:1287444 Cancer Res, 2022, 82(4):721-733 Clin Transl Med, 2022, 12(2):e747
S7470	Triapine (3-AP)	Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.	J Virol, 2023, 97(8):e0026723 Res Sq, 2023, rs.3.rs-3126261 Cancer Res, 2022, 82(4):721-733
S0283	COH-29	COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.	Adv Sci (Weinh), 2021, e2100881
S3385	NSAH	NSAH (HNASH) is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.	Pharmaceutics, 2022, 14-71387
S3641	Osalmid	Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

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