Osalmid

Catalog No.S3641 Batch:S364101

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Technical Data

Formula

C13H11NO3
Molecular Weight 229.23 CAS No. 526-18-1
Solubility (25°C)* In vitro DMSO 45 mg/mL (196.3 mM)
Ethanol 45 mg/mL (196.3 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
Targets
RRM2 [1]
(Cell-free assay)
8.23 μM
In vitro

Osalmid is shown to be 10-fold more active in inhibiting RR activity, and significantly inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid significantly inhibits HBV DNA replication in a time- and dose-dependent manner[1].
In vivo

Osalmid significantly reduces RR activity and HBV DNA replication in vivo[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HepG2.2.15 cells

  • Concentrations

    0, 400, 600, 900, 1200 μM

  • Incubation Time

    36 h

  • Method

    Cells are treated with various concentrations of osalmid for 36 h.
Animal Study:

[1]
  • Animal Models

    BALB/c mice

  • Dosages

    400 mg/kg

  • Administration

    oral gavage

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.