Home DNA Damage/DNA Repair DNA/RNA Synthesis chemical m6A (N6-methyladenosine) For research use only.

m6A (N6-methyladenosine)

Synonyms: NSC-29409, 6-Methyladenosine, N-Methyladenosine

m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

m6A (N6-methyladenosine) Chemical Structure

m6A (N6-methyladenosine) Chemical Structure

CAS No. 1867-73-8

Purity & Quality Control

m6A (N6-methyladenosine) Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
adipocytes, heart and brain cells Function assay Affinity constant for inhibition of A1 receptor control of adenylate cyclase in adipocytes, heart and brain cells, Affinity constant=0.1μM 6279840
Click to View More Cell Line Experimental Data

Biological Activity

Description m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
In vitro
In vitro N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. [1] [2] [3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). [4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs. [5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. [6]
In Vivo
In vivo LD50: Mice >1g/kg (i.g.). [7]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05682001 Recruiting
Cataract|Pathogenesis
Eye & ENT Hospital of Fudan University|National Natural Science Foundation of China
 January 1 2022 --
NCT04696094 Unknown status
Moyamoya Disease
Beijing Tiantan Hospital
 January 1 2021 --

Chemical Information & Solubility

Molecular Weight 281.27 Formula

C11H15N5O4
CAS No. 1867-73-8 SDF --
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (199.09 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 14 mg/mL

Ethanol : 9 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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