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Technical Data
| Formula | C11H15N5O4 |
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| Molecular Weight | 281.27 | CAS No. | 1867-73-8 | |
| Solubility (25°C)* | In vitro | DMSO | 56 mg/mL (199.09 mM) | |
| Ethanol | 7 mg/mL (24.88 mM) | |||
| Water | 5 mg/mL (17.77 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs. |
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| In vitro | N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. [1] [2] [3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). [4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs. [5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. [6] |
| In vivo | LD50: Mice >1g/kg (i.g.). [7] |
Protocol (from reference)
References
Customer Product Validation
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, , Biochem Biophys Res Commun, 2016, 476(4):340-5.
Selleck's m6A (N6-methyladenosine) has been cited by 22 publications
| A low-cost, low-input method establishment for m6A MeRIP-seq [ Biosci Rep, 2024, 44(1)BSR20231430] | PubMed: 38113135 |
| The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts [ Nucleic Acids Res, 2023, 51(2):517-535] | PubMed: 35934316 |
| METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS [ Oncol Rep, 2023, 49(5)94] | PubMed: 36960869 |
| Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA [ Nat Commun, 2022, 13(1):5845] | PubMed: 36195598 |
| The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts [ Nucleic Acids Res, 2022, gkac640] | PubMed: 35934316 |
| Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex [ Cell Rep, 2022, 40(3):111107] | PubMed: 35858564 |
| The Alteration of m6A Modification at the Transcriptome-Wide Level in Human Villi During Spontaneous Abortion in the First Trimester [ Front Genet, 2022, 13:861853] | PubMed: 35754822 |
| Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing [ Virus Genes, 2022, 58(2):98-112] | PubMed: 35190939 |
| NAR Breakthrough Article The S. cerevisiae m 6 A-reader Pho92 promotes timely [ HAL Open Science, 2022, 10.1093/nar/gkac640] | PubMed: None |
| Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6-Methyladenosine-Modified RNAs [ ACS Pharmacol Transl Sci, 2022, 5(10):872-891] | PubMed: 36268123 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.