Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Pyridoxal 5′-phosphate hydrate For research use only.

Pyridoxal 5′-phosphate hydrate

Synonyms: pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP

Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.

Pyridoxal 5′-phosphate hydrate Chemical Structure

Pyridoxal 5′-phosphate hydrate Chemical Structure

CAS No. 853645-22-4

Purity & Quality Control

Pyridoxal 5′-phosphate hydrate Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Biological Activity

Description Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.
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NCT06176482 Recruiting
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Azienda Ospedaliero Universitaria Pisana|Scuola Superiore Sant''Anna di Pisa
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Chemical Information & Solubility

Molecular Weight 247.14 Formula

C8H10NO6P.xH2O
CAS No. 853645-22-4 SDF --
Smiles CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 49 mg/mL ( (198.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 6 mg/mL

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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