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GC7 Sulfate

Synonyms: N1-guanyl-1,7-diaminoheptane Sulfate

GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.

GC7 Sulfate Chemical Structure

GC7 Sulfate Chemical Structure

CAS No. 150417-90-6

Purity & Quality Control

GC7 Sulfate Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Biological Activity

Description GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
Targets
DHPS [1] p21 [1]
In vitro
In vitro

GC7 Sulfate, a deoxyhypusine synthase (DHPS) inhibitor, inhibits MYCN-amplified and chemotherapy-resistant NB cell proliferation, regulates several cell cycle controlling proteins and triggers arrest via the p21/Cdk4/Rb signaling axis, even in the presence of MYCN.[1]
Cell Research Cell lines MYCN2 (±Dox) and BE(2)-C cells
Concentrations 0.1-100 μM
Incubation Time 72 h
Method

Cell viability was analyzed with the MTS assay kit. Briefly, after treatment with GC7 inhibitor for 72 h in 96-well plates, cells were directly incubated with the MTS dye reagent for 1 h at 37 ℃ in a 5 % CO2 atmosphere.

Chemical Information & Solubility

Molecular Weight 270.35 Formula

C8H22N4O4S
CAS No. 150417-90-6 SDF --
Smiles NCCCCCCCNC(N)=N.O[S](O)(=O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 5 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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