Home Microbiology Reverse Transcriptase inhibitor - DNA/RNA Synthesis inhibitor - HIV inhibitor 3'-Fluoro-3'-deoxythymidine (Alovudine) For research use only.

3'-Fluoro-3'-deoxythymidine (Alovudine)

Synonyms: CL 184824, FddThd, FLT, MIV-310

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

3'-Fluoro-3'-deoxythymidine (Alovudine) Chemical Structure

3'-Fluoro-3'-deoxythymidine (Alovudine) Chemical Structure

CAS No. 25526-93-6

Purity & Quality Control

Batch: S684801 DMSO]49 mg/mL]false]Ethanol]40 mg/mL]false]Water]20 mg/mL]false Purity: 99.9%
99.9

3'-Fluoro-3'-deoxythymidine (Alovudine) Related Products

Signaling Pathway

Reverse Transcriptase Signaling Pathways

Reverse Transcriptase Signaling Pathway

Biological Activity

Description 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
Targets
polymerase γ [3] Reverse transcriptase [2]
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Chemical Information & Solubility

Molecular Weight 244.22 Formula

C10H13FN2O4
CAS No. 25526-93-6 SDF --
Smiles CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F
Storage (From the date of receipt) 3 years -20°C(in the dark) powder

In vitro
Batch:

DMSO : 49 mg/mL ( (200.63 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : 20 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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