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HIV Products

All (35)
HIV Inhibitors (34)
HIV Activator (1)
New HIV Products

Catalog No.	Product Name	Information	Product Use Citations
S1208	Doxorubicin (DOX) HCl	Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase I and topoisomerase II with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.	Cell Metab, 2024, S1550-4131(24)00371-1 Nat Cancer, 2024, 10.1038/s43018-024-00814-0 Nucleic Acids Res, 2024, gkae811
S1009	Dactolisib (BEZ235)	Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3^TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.	Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0 J Clin Invest, 2024, 134(18)e179860 Haematologica, 2024, 109(6):1713-1725
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1230	Flavopiridol (Alvocidib)	Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.	Nat Commun, 2024, 15(1):8539 Nat Commun, 2024, 15(1):35 Cell Rep, 2024, 43(5):114176
S8030	Plerixafor (AMD3100)	Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.	Cell, 2024, 187(5):1223-1237.e16 Cell, 2024, 187(5):1223-1237.e16 Stem Cell Res Ther, 2024, 15(1):167
S1117	Triciribine (API-2)	Triciribine (API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.	J Cell Sci, 2023, 136(4)jcs259788 Exp Gerontol, 2023, 173:112091 EJHaem, 2023, 4(3):631-638
S7015	Birinapant	Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with K_d of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.	Cell Death Differ, 2024, 10.1038/s41418-024-01316-3 Cancer Res, 2024, 84(15):2432-2449 Cell Death Dis, 2024, 15(4):255
S7311	Q-VD-Oph	Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.	Nat Commun, 2024, 15(1):830 Cell Death Dis, 2024, 15(5):363 Cell Death Discov, 2024, 10(1):125
S2679	Flavopiridol (Alvocidib) HCl	Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.	Elife, 2024, 13e80684 Int J Biol Macromol, 2023, 258(Pt 1):128776 Mol Cell Biol, 2023, 43(1):1-21
S2003	Maraviroc	Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.	Commun Biol, 2024, 7(1):488 Commun Biol, 2024, 7(1):488 iScience, 2024, 27(7):110141
S3013	Plerixafor (AMD3100) 8HCl	Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.	Sci Signal, 2024, 17(828):eabl3758 Cell Discov, 2023, 9(1):104 Cell Discov, 2023, 9(1):104
S1848	Curcumin	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.	Cancer Cell Int, 2024, 24(1):303 Front Pharmacol, 2024, 15:1418902 PLoS Negl Trop Dis, 2024, 18(8):e0012428
S1896	Hydroxyurea	Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.	Nat Commun, 2024, 15(1):7360 iScience, 2024, 27(4):109580 Sci Adv, 2024, 10(21):eadk8908
S1189	Aprepitant	Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.	Br J Cancer, 2024, 10.1038/s41416-024-02608-8 Inflammation, 2023, 46(1):256-269 Nat Commun, 2022, 13(1):4995
S1400	Tenofovir Disoproxil Fumarate	Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.	Clin Immunol, 2024, 260:109915 Front Cell Infect Microbiol, 2024, 14:1334126 Viruses, 2024, 16(3)323
S1351	Ivermectin	Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.	Viruses, 2024, 16(4)640 Life Sci Alliance, 2023, 6(8)e202302133 Cell Rep Methods, 2023, 3(10):100599
S1704	Emtricitabine (FTC)	Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.	J Biomed Sci, 2024, 31(1):34 Clin Immunol, 2024, 260:109915 Sci Rep, 2024, 14(1):9167
S8512	Cenicriviroc	Cenicriviroc is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.	Int J Biol Sci, 2023, 19(8):2572-2587 Stem Cells, 2023, 41(6):672-683 Life Science Alliance, 2023, 6(6)
S6676	Ebselen	Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.	Evid Based Complement Alternat Med, 2023, 2023:8378581 Science, 2022, 375(6586):1254-1261 NPJ Digit Med, 2022, 5(1):83
S5144	Neferine	Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.	Bone Res, 2022, 10(1):27 Cell Death Dis, 2022, 13(11):1000 iScience, 2022, 25(11):105394
S5959	Tenofovir Disoproxil	Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.	J Virol, 2022, JVI0173021 Front Microbiol, 2018, 9:278
E3863	Swertia Bimaculata Extract	Swertia Bimaculata Extract is extracted from Swertia bimaculata, which is anti-inflammatory and anti-HIV.
S0958	Zingibroside R1	Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. Zingibroside R1 shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM.
E0005	Enfuvirtide Acetate	Enfuvirtide Acetate (T20 Acetate, DP178 Acetate) is an HIV fusion inhibitor with ic50s of 13.63 nM and 30.21 nM on infection by HIV-1IIIB in MT-2 cells and HIV-1Bal in M7 cells, respectively.Solutions are unstable and should be fresh-prepared.
S0076	ABX464	ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
S4861	Oxindole	Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. Oxindole has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.
S3500	Pentosan Polysulfate Sodium	Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.
S6848	3'-Fluoro-3'-deoxythymidine (Alovudine)	3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
E0797	WAY-383487	WAY-383487 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.
S5979	2',3'-Dideoxyadenosine	2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication.
E4891^New	Fostemsavir Tris	Fostemsavir Tris(BMS-663068 Tris) is a phosphonooxymethyl prodrug of BMS-626529, formulated as a tris(hydroxymethyl)aminomethane salt. It inhibits human immunodeficiency virus type 1 (HIV-1) by binding to the gp120 protein, preventing the virus from attaching to CD4+ T-cells.
S9064	Trilobatin	Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
E1138	CQ31	CQ31, a small molecule, selectively activates caspase activation and recruitment domain-containing 8 (CARD8).
S4446	Dimercaprol	Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
S9630^New	Tipranavir	Tipranavir(PNU-140690) is a nonpeptidyl inhibitor of HIV protease with high potency Ki of 0.008 nM and IC50 of 0.03 μM, it also inhibited HIV-2 protease with Ki of < 1 nM. It is administered in combination antiretroviral therapy to treat HIV-1 infection and AIDS.
S1208	Doxorubicin (DOX) HCl	Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase I and topoisomerase II with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.	Cell Metab, 2024, S1550-4131(24)00371-1 Nat Cancer, 2024, 10.1038/s43018-024-00814-0 Nucleic Acids Res, 2024, gkae811
S1009	Dactolisib (BEZ235)	Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3^TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.	Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0 J Clin Invest, 2024, 134(18)e179860 Haematologica, 2024, 109(6):1713-1725
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1230	Flavopiridol (Alvocidib)	Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.	Nat Commun, 2024, 15(1):8539 Nat Commun, 2024, 15(1):35 Cell Rep, 2024, 43(5):114176
S8030	Plerixafor (AMD3100)	Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.	Cell, 2024, 187(5):1223-1237.e16 Cell, 2024, 187(5):1223-1237.e16 Stem Cell Res Ther, 2024, 15(1):167
S1117	Triciribine (API-2)	Triciribine (API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.	J Cell Sci, 2023, 136(4)jcs259788 Exp Gerontol, 2023, 173:112091 EJHaem, 2023, 4(3):631-638
S7015	Birinapant	Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with K_d of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.	Cell Death Differ, 2024, 10.1038/s41418-024-01316-3 Cancer Res, 2024, 84(15):2432-2449 Cell Death Dis, 2024, 15(4):255
S7311	Q-VD-Oph	Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.	Nat Commun, 2024, 15(1):830 Cell Death Dis, 2024, 15(5):363 Cell Death Discov, 2024, 10(1):125
S2679	Flavopiridol (Alvocidib) HCl	Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.	Elife, 2024, 13e80684 Int J Biol Macromol, 2023, 258(Pt 1):128776 Mol Cell Biol, 2023, 43(1):1-21
S2003	Maraviroc	Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.	Commun Biol, 2024, 7(1):488 Commun Biol, 2024, 7(1):488 iScience, 2024, 27(7):110141
S3013	Plerixafor (AMD3100) 8HCl	Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.	Sci Signal, 2024, 17(828):eabl3758 Cell Discov, 2023, 9(1):104 Cell Discov, 2023, 9(1):104
S1848	Curcumin	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.	Cancer Cell Int, 2024, 24(1):303 Front Pharmacol, 2024, 15:1418902 PLoS Negl Trop Dis, 2024, 18(8):e0012428
S1896	Hydroxyurea	Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.	Nat Commun, 2024, 15(1):7360 iScience, 2024, 27(4):109580 Sci Adv, 2024, 10(21):eadk8908
S1189	Aprepitant	Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.	Br J Cancer, 2024, 10.1038/s41416-024-02608-8 Inflammation, 2023, 46(1):256-269 Nat Commun, 2022, 13(1):4995
S1400	Tenofovir Disoproxil Fumarate	Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.	Clin Immunol, 2024, 260:109915 Front Cell Infect Microbiol, 2024, 14:1334126 Viruses, 2024, 16(3)323
S1351	Ivermectin	Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.	Viruses, 2024, 16(4)640 Life Sci Alliance, 2023, 6(8)e202302133 Cell Rep Methods, 2023, 3(10):100599
S1704	Emtricitabine (FTC)	Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.	J Biomed Sci, 2024, 31(1):34 Clin Immunol, 2024, 260:109915 Sci Rep, 2024, 14(1):9167
S8512	Cenicriviroc	Cenicriviroc is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.	Int J Biol Sci, 2023, 19(8):2572-2587 Stem Cells, 2023, 41(6):672-683 Life Science Alliance, 2023, 6(6)
S6676	Ebselen	Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.	Evid Based Complement Alternat Med, 2023, 2023:8378581 Science, 2022, 375(6586):1254-1261 NPJ Digit Med, 2022, 5(1):83
S5144	Neferine	Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.	Bone Res, 2022, 10(1):27 Cell Death Dis, 2022, 13(11):1000 iScience, 2022, 25(11):105394
S5959	Tenofovir Disoproxil	Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.	J Virol, 2022, JVI0173021 Front Microbiol, 2018, 9:278
E3863	Swertia Bimaculata Extract	Swertia Bimaculata Extract is extracted from Swertia bimaculata, which is anti-inflammatory and anti-HIV.
S0958	Zingibroside R1	Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. Zingibroside R1 shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM.
E0005	Enfuvirtide Acetate	Enfuvirtide Acetate (T20 Acetate, DP178 Acetate) is an HIV fusion inhibitor with ic50s of 13.63 nM and 30.21 nM on infection by HIV-1IIIB in MT-2 cells and HIV-1Bal in M7 cells, respectively.Solutions are unstable and should be fresh-prepared.
S0076	ABX464	ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
S4861	Oxindole	Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. Oxindole has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.
S3500	Pentosan Polysulfate Sodium	Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.
S6848	3'-Fluoro-3'-deoxythymidine (Alovudine)	3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
E0797	WAY-383487	WAY-383487 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.
S5979	2',3'-Dideoxyadenosine	2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication.
E4891^New	Fostemsavir Tris	Fostemsavir Tris(BMS-663068 Tris) is a phosphonooxymethyl prodrug of BMS-626529, formulated as a tris(hydroxymethyl)aminomethane salt. It inhibits human immunodeficiency virus type 1 (HIV-1) by binding to the gp120 protein, preventing the virus from attaching to CD4+ T-cells.
S9064	Trilobatin	Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
S4446	Dimercaprol	Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
S9630^New	Tipranavir	Tipranavir(PNU-140690) is a nonpeptidyl inhibitor of HIV protease with high potency Ki of 0.008 nM and IC50 of 0.03 μM, it also inhibited HIV-2 protease with Ki of < 1 nM. It is administered in combination antiretroviral therapy to treat HIV-1 infection and AIDS.
E1138	CQ31	CQ31, a small molecule, selectively activates caspase activation and recruitment domain-containing 8 (CARD8).
E4891^New	Fostemsavir Tris	Fostemsavir Tris(BMS-663068 Tris) is a phosphonooxymethyl prodrug of BMS-626529, formulated as a tris(hydroxymethyl)aminomethane salt. It inhibits human immunodeficiency virus type 1 (HIV-1) by binding to the gp120 protein, preventing the virus from attaching to CD4+ T-cells.
S9630^New	Tipranavir	Tipranavir(PNU-140690) is a nonpeptidyl inhibitor of HIV protease with high potency Ki of 0.008 nM and IC50 of 0.03 μM, it also inhibited HIV-2 protease with Ki of < 1 nM. It is administered in combination antiretroviral therapy to treat HIV-1 infection and AIDS.

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