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Ebselen

Synonyms: DR 3305, SPI-1005, PZ-51, CCG-39161

Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.

Ebselen Chemical Structure

Ebselen Chemical Structure

CAS No. 60940-34-3

Purity & Quality Control

Ebselen Related Products

Biological Activity

Description Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.
Targets
HIV-1 [1]
(Cell-free assay)
46.1 nM
In vitro
In vitro

Ebselen acts on the early postentry step of the HIV-1 viral cycle prior to reverse transcription by stabilizing the incoming viral capsid.[1]
Cell Research Cell lines HeLa-CD4 cells
Concentrations 0-100µM
Incubation Time 72 h
Method

HeLa-CD4-LTR-LacZ cells are infected with NL4.3 replicative virus in the presence of increasing concentrations of ebselen for 72 h.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03013400 Completed
Bipolar Disorder|Bipolar Disorder Manic
University of Oxford|Stanley Medical Research Institute|Sound Pharmaceuticals Incorporated
 October 1 2017 Phase 2
NCT02603081 Completed
Meniere''s Disease
Sound Pharmaceuticals Incorporated
 December 2015 Phase 1|Phase 2
NCT01452607 Completed
Hearing Loss|Cancer
Sound Pharmaceuticals Incorporated
 May 2006 Phase 1
NCT00762671 Completed
Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Brigham and Women''s Hospital
 May 1999 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 274.18 Formula

C13H9NOSe
CAS No. 60940-34-3 SDF --
Smiles C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 55 mg/mL ( (200.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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