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Pentosan Polysulfate Sodium

Name: Pentosan Polysulfate Sodium
Brand: Selleck Chemicals
SKU: S3500
Rating: 5 (1 reviews)

Synonyms: PPS, Elmiron

Catalog No.S3500 Purity:99%

Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.

Pentosan Polysulfate Sodium Chemical Structure

CAS No. 140207-93-8

Purity & Quality Control

Batch: Purity: 99%

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Biological Activity

Description

Targets

HIV-1 ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06334523	Not yet recruiting	Extremely Low Birthweight Infant\|Continuous Tracheal Gas Insufflation\|Medical Device\|Lung Protection\|Ventilator-Induced Lung Injury	Centre Hospitalier Intercommunal Creteil	May 1 2024	Phase 2
NCT06375876	Not yet recruiting	Domestic Violence	Yale University\|Office on Violence Against Women (OVW)	April 2024	Not Applicable
NCT05900336	Recruiting	Dysmenorrhea\|Menstrual Pain\|Non-steroidal Anti-inflammatory Drug	Mclean Hospital\|United States Department of Defense\|NorthShore University HealthSystem	March 25 2024	Phase 4

References

[1] M Baba, et al. Antiviral Res. 1988 Sep;9(6):335-43.

Chemical Information & Solubility

Molecular Weight		Formula	(C₅H₆Na₂O₁₀S₂)_n
CAS No.	140207-93-8	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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