Denosumab (anti-RANK ligand)

Synonyms: AMG-162

Catalog No.A2020 Purity:99.68%

Denosumab (anti-RANK ligand) (AMG-162) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

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Selleck's Denosumab (anti-RANK ligand) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.68% Protein concentration: 5mg/ml Endotoxin Level: <1EU/mg

99.68

Choose Selective NF-κB Inhibitors

Name	Citation	NF-κB	Others
QNZ (EVP4593)	138	++++	TNF-α
JSH-23	153	++
B022	0	++++
UCB-9260	0	+++	TNF
Morusin	0	+	STAT3
IQ 3	1	++	TNF-α,IL-6,JNK3
CBL0137	8	+++	FACT,p53
NIK SMI1	0	++++
Ginsenoside Rb3	1	++	iNOS,COX-2
Ginsenoside Rd	4	+	iNOS,COX-2,Ca2+ influx
CBL0137 HCl	7	+++	FACT,p53
SC75741	47	+++
TPCA-1	✔	STAT3,IKK2
Bardoxolone Methyl	✔	IKK,Nrf2,Ferroptosis
Curcumin	✔	Nrf2,HDAC,Ferroptosis
Sodium 4-Aminosalicylate	✔
Caffeic Acid Phenethyl Ester	✔
Sodium salicylate	✔
EN450	✔
Chitosan oligosaccharide	✔
NF-κB-IN-1	✔
SM-7368	✔
sappanone A	✔
Rubiadin 1-methyl ether	✔
Cornuside	✔
BTYNB	✔
TCEP Hydrochloride	✔
IMM-H007	✔	ABCA1,JNK/AP1,AMPK
Urolithin B	✔	Akt,ERK,JNK
L-Quebrachitol	✔	BMP-2,Wnt/β-catenin,MAPK
Licochalcone D	✔	Met,EGFR,JAK2
Tectochrysin	✔
Caulophylline (N-Methylcytisine)	✔	IKK,IκB,MPO
Myrislignan	✔	COX-2,iNOS,TNF-α
NDMC101	✔
Gardenoside	✔	P2X3 receptor,IL-6,IL-1β
Cucurbitacin IIb	✔	TNF-α,IκBα,ERK1/2
Jaceosidin	✔	c-FLIP,Mcl-1,Bax
Isoliquiritin apioside	✔	MAPK,MMP
Withaferin A (WFA)	✔	vimentin
Rocaglamide	✔	eIF4A,HSF1
Xanthatin	✔	STATs
Alobresib (GS-5829)	✔	MYC,ERK1/2,Akt
Adjudin	✔	ERK,Cl⁻ channel
IAXO-102	✔	MAPK,TLR4
C25-140	✔	TRAF6-Ubc13
SN50	✔
INH14	✔	IKKβ,IKKα
TAK-243 (MLN7243)	✔	UAE
Sulforaphane	✔	HDAC,Nrf2,HO-1
Madecassic acid	✔	IL-1β,TNF-α,COX-2
Homoplantaginin	✔	TNF-α,IL-6,IKKβ
(+)-Praeruptorin A	✔
2',5'-Dihydroxyacetophenone	✔	iNOS,IL-6,TNF-α
Dauricine	✔
8-O-acetyl shanzhiside methyl ester	✔
Forsythoside B	✔	IκB,IL-6,TNF-alpha
Engeletin	✔
Berbamine	✔	CaMKII,Bcr-Abl
Eleutheroside E	✔
Mulberroside A	✔	ERK,Caspase-1,NALP3
Maslinic acid	✔
Chelidonic acid	✔	glutamate decarboxylase,IL-6,Caspase-1
Hyperoside	✔
Vanillic acid	✔
4'-Hydroxychalcone	✔
(+)-α-Lipoic acid	✔	LTR
4-Hydroxychalcone	✔
Neferine	✔
Benfotiamine	✔
Ginsenoside Rb1	✔	iNOS,IFN-β,TNF-α
Ginsenoside Rg1	✔	Aβ
Guaiacol	✔	COX-2
(E)-Cardamonin	✔	TRPA1
Hederagenin	✔	iNOS,COX-2
Ginsenoside Re	✔	JNK,Aβ
Scutellarin	✔	STAT3,Akt
Mangiferin	✔	Nrf2
Schisantherin A	✔
Curcumenol	✔	CYP3A4
Muscone	✔	IL-6,TNF-α,IL-1β
Tyrosol	✔
Stachydrine	✔
Sodium Aescinate	✔
Dehydroevodiamine	✔	PGE2,iNOS,COX-2
Astragaloside IV	✔	mTOR,Akt,ERK
4'-Methoxyresveratrol	✔	NLRP3
Berbamine dihydrochloride	✔	CaMKII,Bcr-Abl
Sarsasapogenin	✔	IκBα,TAK1,IRAK1
Shikonin	✔	chemokine receptor,Proteasome,TNF-α
Diethylmaleate	✔	Nrf2
Omaveloxolone (RTA-408)	✔	Nrf2
DTP3	✔	GADD45β/MKK7
APX-3330	✔	APE1(Ref-1)
Triptolide	✔	MDM2,HSF1
Methylthiouracil	✔	ERK1/2,IL-6,TNF-α
Erdosteine	✔
Evodiamine	✔
Vanillylacetone	✔
(-)-Parthenolide	✔	p53,MDM2,HDAC1
Magnolol	✔
Indole-3-carbinol	✔
DHA (Dihydroartemisinin)	✔
Andrographolide	✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Denosumab (anti-RANK ligand) (AMG-162) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

References
[1] Paul J Kostenuik, et al. J Bone Miner Res. 2009 Feb;24(2):182-95. [2] Emma D Deeks. Drugs Aging. 2018 Feb;35(2):163-173.

References

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	615258-40-7
Molecular Weight	145.16 kDa
Isotype	human IgG1
Source	HEK293
Formulation	PBS Buffer, pH 7.4
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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