Home NF-κB NF-κB inhibitor Sodium Aescinate For research use only.

Sodium Aescinate

Synonyms: Escin sodium salt

Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

Sodium Aescinate Chemical Structure

Sodium Aescinate Chemical Structure

CAS No. 20977-05-3

Purity & Quality Control

Sodium Aescinate Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.
Targets
NF-κB [3]
In Vivo
In vivo

Sodium aescinate (SA) prevents and alleviates acute lung injury induced by oleic acid[1]. It is used as a vasoactive drug in clinical treatment. Topical application of SA can accelerate wound healing significantly marked by compact collagen deposition and newly regenerated epithelial layer. Sodium aescinate (SA) may effectively control and improve wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[2].
Animal Research Animal Models Sprague-Dawley rats
Dosages 1 mg/kg, 2 mg/kg and 6mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 1123.21 Formula

C54H83NaO23
CAS No. 20977-05-3 SDF Download Sodium Aescinate SDF
Smiles CC(C(C)OC(=O)C)C(=O)OCC12C3CC(C(C1O)OC2CC4(C3=CCC5C4(CCC6C5(CCC(C6(C)CO)OC7C(C(C(C(O7)C(=O)O)OC8C(C(C(C(O8)CO)O)O)O)O)OC9C(C(C(CO9)O)O)O)C)C)C)(C)C.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 10 mg/mL ( (8.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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