Home NF-κB NF-κB inhibitor Benfotiamine For research use only.

Benfotiamine

Synonyms: S-Benzoylthiamine O-monophosphate, Benzoylthiamine monophosphate

Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) and has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2. Benfotiamine suppresses oxidative stress-induced NF-κB activation and prevents the bacterial endotoxin-induced inflammation.

Benfotiamine Chemical Structure

Benfotiamine Chemical Structure

CAS No. 22457-89-2

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Benfotiamine Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) and has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2. Benfotiamine suppresses oxidative stress-induced NF-κB activation and prevents the bacterial endotoxin-induced inflammation.
Targets
NF-κB [4]
In vitro
In vitro

Benfotiamine improves the expression of endothelial cell markers in EPCs, restores eNOS levels, and recovers the ability of EPCs to participate in angiogenic processes. It is able to dampen glucose toxicity effects on endothelial progenitors[1]. Benfotiamine possesses antitumor activity against leukemia cells. In a panel of nine myeloid leukemia cell lines benfotiamine impairs the viability of HL-60, NB4, K562 and KG1 cells and also inhibits the growing of primary leukemic blasts. The antitumor activity of benfotiamine is not mediated by apoptosis, necrosis or autophagy, but rather occurs though paraptosis cell death induction. Benfotiamine inhibits the activity of constitutively active ERK1/2 and concomitantly increases the phosphorylation of JNK1/2 kinase in leukemic cells. In addition, benfotiamine induces the down regulation of the cell cycle regulator CDK3 which results in G1 cell cycle arrest in the sensitive leukemic cells[2].
Cell Research Cell lines leukemia cells (HL60, AML 1, NB4 cells)
Concentrations 50 μM
Incubation Time 24, 48, 72, 96 h
Method

Cell viability is assessed using a colorimetric MTT metabolic activity assay.
In Vivo
In vivo

Benfotiamine might exert vascular and renal benefits by modulating mechanisms independent or downstream of ROS formation. Benfotiamine aids the post-ischaemic healing of diabetic animals via PKB/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis[3].
Animal Research Animal Models diabetic animal model induced by STZ (male CD1 mice)
Dosages 80 mg/kg
Administration oral administration

Chemical Information & Solubility

Molecular Weight 466.45 Formula

C19H23N4O6PS
CAS No. 22457-89-2 SDF --
Smiles CC1=NC=C(C(=N1)N)CN(C=O)C(=C(CCOP(=O)(O)O)SC(=O)C2=CC=CC=C2)C
Storage (From the date of receipt)

In vitro
Batch:

5%TFA : 6 mg/mL


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