Home NF-κB NF-κB inhibitor Evodiamine For research use only.

Evodiamine

Synonyms: Isoevodiamine

Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-κB activation through suppression of IkB kinase activity.

Evodiamine Chemical Structure

Evodiamine Chemical Structure

CAS No. 518-17-2

Purity & Quality Control

Evodiamine Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-κB activation through suppression of IkB kinase activity.
Targets
NF-κB [2]
In vitro
In vitro Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. [1] Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. [2] In addition, Evodiamine is an human topoisomerase I inhibitor. [3]
In Vivo
In vivo LD50: Mice 77mg/kg (i.v.) [4]

Chemical Information & Solubility

Molecular Weight 303.36 Formula

C19H17N3O
CAS No. 518-17-2 SDF Download Evodiamine SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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