Home NF-κB NF-κB inhibitor Tyrosol For research use only.

Tyrosol

Synonyms: 4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol

Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.

Tyrosol Chemical Structure

Tyrosol Chemical Structure

CAS No. 501-94-0

Purity & Quality Control

Tyrosol Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.
Targets
NF-κB [2]
In vitro
In vitro

Tyrosol (Tyr) suppresses TNF-α-induced intracellular production of ROS, depletion of GSH, and down-regulation of genes encoding antioxidant enzymes in hECs. Tyr inhibits palmitic acid-induced oxidative stress in human liver HepG2 cells[1].
Cell Research Cell lines hECs (human endothelial cells)
Concentrations 0-200 μM
Incubation Time 48 h
Method

hECs are cultured in 96-well plates in eight replicate sets at a density of 104 cells per well in the presence of Tyr or its metabolites at the indicated concentrations for 48 h. Cell viability is assayed based on the ability of live cells to reduce methylthiazolyldiphenyl-tretrazolium bromide (MTT).
In Vivo
In vivo

After ingestion, Tyrosol (Tyr) undergoes extensive first pass intestinal/hepatic metabolism[1].
Animal Research Animal Models Swiss albino mice
Dosages 0.5 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06285682 Active not recruiting
Healthy
Anglia Ruskin University|Fattoria La Vialla|Instituto Kurz
 February 3 2024 Not Applicable
NCT02783989 Completed
Cardiovascular Disease
Parc de Salut Mar
 January 20 2016 Not Applicable

Chemical Information & Solubility

Molecular Weight 138.16 Formula

C8H10O2
CAS No. 501-94-0 SDF Download Tyrosol SDF
Smiles C1=CC(=CC=C1CCO)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 27 mg/mL ( (195.42 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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