Tyrosol

Catalog No.S3773 Batch:S377301

Technical Data

Formula	C₈H₁₀O₂
Molecular Weight	138.16	CAS No.	501-94-0
Solubility (25°C)*	In vitro	DMSO	27 mg/mL (195.42 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.

Targets

NF-κB ^[2]

In vitro

Tyrosol (Tyr) suppresses TNF-α-induced intracellular production of ROS, depletion of GSH, and down-regulation of genes encoding antioxidant enzymes in hECs. Tyr inhibits palmitic acid-induced oxidative stress in human liver HepG2 cells^[1].

In vivo

After ingestion, Tyrosol (Tyr) undergoes extensive first pass intestinal/hepatic metabolism^[1].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines hECs (human endothelial cells) Concentrations 0-200 μM Incubation Time 48 h Method hECs are cultured in 96-well plates in eight replicate sets at a density of 10⁴ cells per well in the presence of Tyr or its metabolites at the indicated concentrations for 48 h. Cell viability is assayed based on the ability of live cells to reduce methylthiazolyldiphenyl-tretrazolium bromide (MTT).
Animal Study:^{^[1]}	Animal Models Swiss albino mice Dosages 0.5 mg/kg Administration i.p.

Cell Assay:^{^[1]}

Cell lines
hECs (human endothelial cells)
Concentrations
0-200 μM
Incubation Time
48 h
Method
hECs are cultured in 96-well plates in eight replicate sets at a density of 10⁴ cells per well in the presence of Tyr or its metabolites at the indicated concentrations for 48 h. Cell viability is assayed based on the ability of live cells to reduce methylthiazolyldiphenyl-tretrazolium bromide (MTT).

Animal Study:^{^[1]}

Animal Models
Swiss albino mice
Dosages
0.5 mg/kg
Administration
i.p.

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.