Home Protein Tyrosine Kinase NF-κB inhibitor - JAK inhibitor - EGFR inhibitor - c-Met inhibitor - Apoptosis related activator - Caspase activator - PARP inhibitor Licochalcone D For research use only.

Licochalcone D

Synonyms: Lico D, LCD, LD

Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.

Licochalcone D Chemical Structure

Licochalcone D Chemical Structure

CAS No. 144506-15-0

Purity & Quality Control

Batch: S689901 DMSO]100 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

Licochalcone D Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.
Targets
NF-κB [1] JAK2 [2] EGFR [3] Met [3] Caspase [3] Click to View More Targets
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06045416 Not yet recruiting
Lyme Disease|Borrelia Infections
University Children''s Hospital Zurich|Institute of Medical Microbiology University of Zurich Zurich Switzerland
 April 1 2024 --
NCT06003179 Not yet recruiting
Lymphoma Large B-Cell Diffuse
University Health Network Toronto
 April 2024 Phase 1
NCT06014762 Recruiting
Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Primary Mediastinal Large B-cell Lymphoma (PMBCL)|Chronic Lymphocytic Leukemia
Poseida Therapeutics Inc.|Roche-Genentech
 April 2024 Phase 1
NCT06358859 Not yet recruiting
Cardiometabolic Risk Factors|Diabetes|High Blood Pressure|Obesity|Nutrition Security
Tufts University|National Institute on Minority Health and Health Disparities (NIMHD)|Tougaloo College Mississippi|Delta Health Center Mississippi|Reuben V. Anderson Center for Justice at Tougaloo
 April 2024 Not Applicable
NCT05559801 Not yet recruiting
Osteogenesis Imperfecta|Osteogenesis Imperfecta Type III
Emory University
 April 2024 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 354.40 Formula

C21H22O5
CAS No. 144506-15-0 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (282.16 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Licochalcone D | Licochalcone D supplier | purchase Licochalcone D | Licochalcone D cost | Licochalcone D manufacturer | order Licochalcone D | Licochalcone D distributor