Home Neuronal Signaling AChR antagonist - Peroxidases inhibitor - NF-κB inhibitor - IκB/IKK inhibitor Caulophylline (N-Methylcytisine) For research use only.

Caulophylline (N-Methylcytisine)

Synonyms: Caulophyllin, NMC

Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.

Caulophylline (N-Methylcytisine) Chemical Structure

Caulophylline (N-Methylcytisine) Chemical Structure

CAS No. 486-86-2

Purity & Quality Control

Batch: S329801 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.85%
99.85

Caulophylline (N-Methylcytisine) Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
Targets
MPO [2] IκB [2] IKK [2] NF-κB [2] nAChR [1]
(Cell-free assay)
50 nM(Kd)
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University of Nebraska
 November 1 2013 --

Chemical Information & Solubility

Molecular Weight 204.27 Formula

C12H16N2O
CAS No. 486-86-2 SDF --
Smiles CN1CC2CC(C1)C3=CC=CC(=O)N3C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (489.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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