Home Apoptosis Apoptosis related activator - Bax/Bak activator - COX inhibitor - NF-κB inhibitor Jaceosidin For research use only.

Jaceosidin

Jaceosidin, a flavonoid isolated from Artemisia vestita, possesses anti-tumor and anti-proliferative activities in many cancer cells. Jaceosidin induces apoptosis, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin inhibits COX-2 expression and NF-κB activation.

Jaceosidin Chemical Structure

Jaceosidin Chemical Structure

CAS No. 18085-97-7

Purity & Quality Control

Batch: S093101 DMSO]66 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 98.35%
98.35

Jaceosidin Related Products

Biological Activity

Description Jaceosidin, a flavonoid isolated from Artemisia vestita, possesses anti-tumor and anti-proliferative activities in many cancer cells. Jaceosidin induces apoptosis, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin inhibits COX-2 expression and NF-κB activation.
Targets
Bax [1] Mcl-1 [1] c-FLIP [1] COX-2 [2] NF-κB [2]
In vitro
In vitro

Jaceosidin induces apoptosis through Bax activation and downregulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells.[1]
Cell Research Cell lines Human renal carcinoma (Caki, ACHN, A498, and 786-O cell lines)
Concentrations --
Incubation Time --
Method

Caki cells were treated with 75 µM jaceosidin for 3 h. The mitochondrial membrane potential (MMP) was measured using a flow cytometer. Caki cells were treated with 75 µM jaceosidin for 12 and 24 h. Cytoplasmic fractions were analyzed for cytochrome c release. Caki cells were treated 75 µM jaceosidin for 1, 3, 6 h and stained for active Bax using conformation-specific antibodies. The fluorescence intensity was detected by flow cytometry. For the Bax oligomerization assay, Caki cells were treated with 75 µM jaceosidin for 1, 3, 6 h. After treatment, Bax monomers and oligomers were detected by western blotting. 
In Vivo
In vivo

Jaceosidin blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates, inhibits COX-2 expression and NF-kappaB activation, and markedly reduces TNF-alpha, IL-1beta, and prostaglandin E2 (PGE(2)) levels, also inhibits hind paw edema induced by carrageenan.[2]
Animal Research Animal Models mice of air pouch model of inflammation, rats of paw edema model of inflammation
Dosages 10, 20 mg/kg
Administration p.o., s.c.

Chemical Information & Solubility

Molecular Weight 330.29 Formula

C17H14O7
CAS No. 18085-97-7 SDF --
Smiles COC1=C(C=CC(=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (199.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


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In vivo
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