Home Apoptosis Apoptosis related chemical Sophoridine For research use only.

Sophoridine

Synonyms: 5-Epidihydrosophocarpine, Dihydro-5-episophocarpine

Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.

Sophoridine Chemical Structure

Sophoridine Chemical Structure

CAS No. 6882-68-4

Purity & Quality Control

Batch: S389501 DMSO]49 mg/mL]false]]]false]]]false Purity: 98%
98

Sophoridine Related Products

Biological Activity

Description Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.
In vitro
In vitro Sophoridine kills cancer cells but has low cytotoxicity to normal cells. Pancreatic cancer cells are particularly sensitive. Sophoridine inhibits the proliferation of pancreatic cancer cells and induces cell cycle arrest at S phase and mitochondrial-related apoptosis. Moreover, Sophoridine induces a sustained activation of the phosphorylation of ERK and JNK. In addition, Sophoridine provokes the generation of reactive oxygen species (ROS) in pancreatic cancer cells[1]. Sophoridine also triggers significant down-regulated the expression of p27, CDK2, Survivin, Livin, Bcl-2, E2F1 and the transcriptional activity of FoxM1, NF-κb and AP-1, meanwhile, up-regulated the expression of caspase-3/8, p53, Smac, c-JNK and p38-MAPK. Sophoridine significantly inhibits ubiquitin-proteasome in tumor cells[2].
Cell Research Cell lines Miapaca-2 and PANC-1; HPDE
Concentrations 0, 10, 20, 40, 80, or 100 μM
Incubation Time 24 h, 48 h, or 72 h
Method Two human pancreatic cancer cell lines (Miapaca-2 and PANC-1) and pancreatic ductal epithelial cell line (HPDE) are treated with Sophoridine at different concentrations (0, 10, 20, 40, 80, or 100 μM) for different lengths of time (24 h, 48 h, or 72 h). Cell viability is determined by the CCK-8 assay.
In Vivo
In vivo Sophoridine is an effective agent that can inhibit the growth of xenograft pancreatic tumors in vivo with well-tolerated toxicity[1]. Sophoridine attenuates intestinal inflammation in the experimental colitis model, which is associated with the downregulation of ICAM-1 gene expression[3].
Animal Research Animal Models BALB/c homozygous (nu/nu) nude mice (6 weeks, 18 g)
Dosages 20 mg/kg or 40 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 248.36 Formula

C15H24N2O
CAS No. 6882-68-4 SDF --
Smiles C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (197.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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