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Bisdemethoxycurcumin (BDMC)

Name: Bisdemethoxycurcumin (BDMC)
Brand: Selleck Chemicals
SKU: S3938
Rating: 5 (1 reviews)

Catalog No.S3938 Purity:99.86%

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.

Bisdemethoxycurcumin (BDMC) Chemical Structure

CAS No. 33171-05-0

Purity & Quality Control

Batch: Purity: 99.86%

99.86

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Biological Activity

Description	Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.

In vitro
In vitro	Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin, which is a natural substance found in the turmeric root. BDMC inhibits the growth of gastric cancer SGC 7901 cells in a dose‑dependent manner. BDMC arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle^[2].
Cell Research	Cell lines	The NSCLC cell lines A549, H460 and SPC-A-1
	Concentrations	0-100 μM
	Incubation Time	72 h
	Method	The cells are grown at 37˚C in a humidified atmosphere of 5% CO2. To evaluate the hypomethylation effect of bisdemethoxycurcumin, DAC is used as positive control. Curcumin, DMC, BDMC and DAC are prepared as stock solutions (20 mM) in dimethyl sulfoxide (DMSO) and diluted in sterile-filtered media before use. Cells (1×10⁵) are seeded into 6-well culture plates. After 24 h of culture, the cells are treated with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM) for 72 h.

In Vivo
In vivo	BDMC may promote apoptosis in tumors via mitochondrial modulation. BDMC inhibits the tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model^[2].
Animal Research	Animal Models	human gastric adenoadenocarcinoma xenograft model (nude mice)
	Dosages	100 mg/kg/day
	Administration	s.c.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05542394	Completed	Plasma Levels of Different Curcuminoids Preparations	University of Jordan\|Nutritional Fundamentals for Health	September 20 2022	Not Applicable
NCT01982734	Completed	Pharmacokinetics of New Curcumin Formulations\|Safety of New Curcumin Formulations	University of Hohenheim\|German Federal Ministry of Education and Research	November 2012	Early Phase 1
NCT01925287	Completed	Pharmacokinetics of Novel Curcumin Formulations\|Safety of Novel Curcumin Formulations	University of Hohenheim\|German Federal Ministry of Education and Research	October 2011	Early Phase 1

References

Chemical Information & Solubility

Molecular Weight	308.33	Formula	C₁₉H₁₆O₄
CAS No.	33171-05-0	SDF	Download Bisdemethoxycurcumin (BDMC) SDF
Smiles	C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 62 mg/mL ( (201.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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