Bisdemethoxycurcumin (BDMC)

Catalog No.S3938 Batch:S393802

Technical Data

Formula	C₁₉H₁₆O₄
Molecular Weight	308.33	CAS No.	33171-05-0
Solubility (25°C)*	In vitro	DMSO	62 mg/mL (201.08 mM)
		Ethanol	25 mg/mL (81.08 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.
In vitro	Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin, which is a natural substance found in the turmeric root. BDMC inhibits the growth of gastric cancer SGC 7901 cells in a dose‑dependent manner. BDMC arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle^[2].
In vivo	BDMC may promote apoptosis in tumors via mitochondrial modulation. BDMC inhibits the tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines The NSCLC cell lines A549, H460 and SPC-A-1 Concentrations 0-100 μM Incubation Time 72 h Method The cells are grown at 37˚C in a humidified atmosphere of 5% CO2. To evaluate the hypomethylation effect of bisdemethoxycurcumin, DAC is used as positive control. Curcumin, DMC, BDMC and DAC are prepared as stock solutions (20 mM) in dimethyl sulfoxide (DMSO) and diluted in sterile-filtered media before use. Cells (1×10⁵) are seeded into 6-well culture plates. After 24 h of culture, the cells are treated with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM) for 72 h.
Animal Study:^{^[2]}	Animal Models human gastric adenoadenocarcinoma xenograft model (nude mice) Dosages 100 mg/kg/day Administration s.c.

Cell Assay:^{^[1]}

Cell lines
The NSCLC cell lines A549, H460 and SPC-A-1
Concentrations
0-100 μM
Incubation Time
72 h
Method
The cells are grown at 37˚C in a humidified atmosphere of 5% CO2. To evaluate the hypomethylation effect of bisdemethoxycurcumin, DAC is used as positive control. Curcumin, DMC, BDMC and DAC are prepared as stock solutions (20 mM) in dimethyl sulfoxide (DMSO) and diluted in sterile-filtered media before use. Cells (1×10⁵) are seeded into 6-well culture plates. After 24 h of culture, the cells are treated with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM) for 72 h.

Animal Study:^{^[2]}

Animal Models
human gastric adenoadenocarcinoma xenograft model (nude mice)
Dosages
100 mg/kg/day
Administration
s.c.

References

Selleck's Bisdemethoxycurcumin (BDMC) has been cited by 1 publication

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination. [ Drug Des Devel Ther, 2020, 14:993-1001]	PubMed: 32184568

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination. [ Drug Des Devel Ther, 2020, 14:993-1001]

PubMed: 32184568

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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