Home Apoptosis Apoptosis related chemical Flavone For research use only.

Flavone

Synonyms: 2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron

Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.

Flavone Chemical Structure

Flavone Chemical Structure

CAS No. 525-82-6

Purity & Quality Control

Batch: S396701 DMSO]44 mg/mL]false]]]false]]]false Purity: 99.86%
99.86

Flavone Related Products

Biological Activity

Description Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
In vitro
In vitro Flavone is found to reduce cell proliferation in HT-29 cells with an EC50 value of 54.8 ± 1.3 μm and to potently induce differentiation as well as apoptosis. The effects of flavone in HT-29 cells are associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor κB (NF-κB), and bcl-XL. Moreover, flavone displays a high selectivity for the induction of apoptosis and of growth inhibition only in the transformed colonocytes[1].
Cell Research Cell lines HT-29 Cells
Concentrations 1-1000 μM
Incubation Time 72 h
Method

Cells (5 × 103 per well) are incubated for 72 h with medium alone (control) or containing the compounds at various concentrations and cell numbers are determined subsequently using SYTOX-Green nucleic acid stain.
In Vivo
In vivo In vivo anti-tumor study indicates that flavone exhibits ability to inhibit tumor formation elicited by s.c. injection of COLO205 cells in nude mice. Apoptotic cells and an increase in p21, but not p53, protein are observed in tumor tissues derived from flavone-treated group. Flavone has been shown to accumulate in intestinal cells suggesting the potential application of flavone in treatment of colorectal carcinoma[2].
Animal Research Animal Models Male BALB/c nu/nu mice (Tumor-bearing mice injected COLO205 cells s.c.)
Dosages 10 and 20 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06236360 Recruiting
Melanoma Stage Iv|Metastatic Melanoma
University Hospital Rijeka
 December 21 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 222.24 Formula

C15H10O2
CAS No. 525-82-6 SDF Download Flavone SDF
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 44 mg/mL ( (197.98 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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