Home PI3K/Akt/mTOR AMPK activator - NF-κB inhibitor - JNK inhibitor IMM-H007 For research use only.

IMM-H007

IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.

IMM-H007 Chemical Structure

IMM-H007 Chemical Structure

CAS No. 1221412-23-2

Purity & Quality Control

Batch: S446001 DMSO]97 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.13%
98.13

IMM-H007 Related Products

Signaling Pathway

AMPK Signaling Pathways

AMPK Signaling Pathway

Biological Activity

Description IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
Targets
AMPK [1] NF-κB [2] JNK/AP1 [3] ABCA1 [3]
In Vivo
In vivo

IMM-H007 reduces isoprenaline-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.[4]
Animal Research Animal Models Wild Type and AMPKα2−/− mice
Dosages 200 mg·kg−1·day−1 body weight
Administration o.g.

Chemical Information & Solubility

Molecular Weight 485.45 Formula

C22H23N5O8
CAS No. 1221412-23-2 SDF --
Smiles CC(=O)OCC1OC(C(OC(C)=O)C1OC(C)=O)[N]2C=NC3=C(NC4=CC=CC(=C4)O)N=CN=C23
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 97 mg/mL ( (199.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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