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Chitosan oligosaccharide

Synonyms: COS

Chitosan oligosaccharide (COS) is an oligomer of β-(1➔4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).

Chitosan oligosaccharide Chemical Structure

Chitosan oligosaccharide Chemical Structure

CAS No. 148411-57-8

Purity & Quality Control

Batch: E266101 Water]68 mg/mL]false]DMSO]34 mg/mL]false]Ethanol]Insoluble]false Purity: 99%
99

Chitosan oligosaccharide Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Chitosan oligosaccharide (COS) is an oligomer of β-(1➔4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
Targets
NF-κB [1] MAPK [1] AMPK [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06219057 Recruiting
Adolescent Behavior|Adolescent - Emotional Problem
University of Coimbra
 June 1 2023 Not Applicable
NCT05219435 Recruiting
Urothelial Cancer
Spanish Oncology Genito-Urinary Group|Bristol-Myers Squibb
 July 6 2022 Phase 2

Chemical Information & Solubility

Molecular Weight 340.327 Formula

C12H24N2O9
CAS No. 148411-57-8 SDF --
Smiles NC1C(O)OC(CO)C(OC2OC(CO)C(O)C(O)C2N)C1O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 68 mg/mL

DMSO : 34 mg/mL ( (99.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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