Denosumab (anti-RANK ligand)

Catalog No.A2020 Batch: A202002

Technical Data

CAS No.	615258-40-7
Formulation	PBS Buffer, pH 7.4
Isotype	human IgG1
Source	HEK293
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Purity	99%
Protein concentration	3.74 mg/ml
Endotoxin Level	<1 EU/mg

Biological Activity

Description	Denosumab (anti-RANK ligand) (AMG-162) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

References	[1] Paul J Kostenuik, et al. J Bone Miner Res. 2009 Feb;24(2):182-95. [2] Emma D Deeks. Drugs Aging. 2018 Feb;35(2):163-173.

References

Selleck's Denosumab (anti-RANK ligand) has been cited by 3 publications

Clinical-proteomic classification and precision treatment strategy of chordoma [ Cell Rep Med, 2024, 5(10):101757]	PubMed: 39368483
TNFSF11/TNFRSF11A Axis Amplifies HDM-Induced Airway Remodeling by Strengthening TGFβ1/STAT3 Action [ Allergy Asthma Immunol Res, 2024, 16(4):399-421]	PubMed: 39155739
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression [ ACS Omega, 2023, 8(23):20739-20754]	PubMed: 37323396

FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.