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Technical Data
| CAS No. | 615258-40-7 |
|---|---|
| Formulation | PBS Buffer, pH 7.4 |
| Isotype | human IgG1 |
| Source | HEK293 |
| Storage (From the date of receipt) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
| Purity | 99% |
| Protein concentration | 3.74 mg/ml |
| Endotoxin Level | <1 EU/mg |
Biological Activity
| Description | Denosumab (anti-RANK ligand) (AMG-162) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM. |
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| References |
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Selleck's Denosumab (anti-RANK ligand) has been cited by 1 publication
| Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression [ ACS Omega, 2023, 8(23):20739-20754] | PubMed: 37323396 |
FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.