Home NF-κB NF-κB inhibitor - Immunology & Inflammation related chemical - NLRP3 inhibitor - Interleukins inhibitor - TNF-alpha inhibitor Muscone For research use only.

Muscone

Synonyms: 3-Methylcyclopentadecanone, Methylexaltone

Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).

Muscone Chemical Structure

Muscone Chemical Structure

CAS No. 541-91-3

Purity & Quality Control

Muscone Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Biological Activity

Description Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
Targets
NF-κB [4] NLRP3 inflammasome [4] IL-1β [4] TNF-α [4] IL-6 [4]
In vitro
In vitro

Muscone induces CYP1A2 and CYP3A4 expression in liver cells in vitro and in vivo[1]. Muscone protects PC12 cells against glutamate-induced apoptosis by attenuating ROS generation and Ca2+ influx, via NR1 and CaMKII-depended ASK-1/JNK/p38 signaling pathways[2]. Muscone could promote bone marrow-derived mesenchymal stem cells (BMSCs) migration and proliferation[3].
Cell Research Cell lines PC12 cells
Concentrations 0.1, 1, 10 μM
Incubation Time 1 h
Method

PC12 cells are seeded in 96-well culture plates at an approximate density of 1×105 cells per well and maintained in a CO2 incubator at 37 ℃ overnight. At the end of indicated treatment, MTT is added to the medium and incubated for another 4 h at 37℃. After the removal of the culture medium, the insoluble dark blue formazan crystal is dissolved with 150 μL DMSO. The absorbance (A) is measured at 490 nm with a microplate reader. Cell viability is expressed as a percentage with the control group as 100%.
In Vivo
In vivo

Muscone exhibits liver toxicity in Kunming mice at concentrations higher than 50 mg/kg[1]. It exerts potent neuroprotective activities on cerebral ischemia[2]. Muscone could accelerate the migration of BMSCs to the injured area in vivo[3].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05559307 Recruiting
Ischemic Stroke Acute
Ying Gao|Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital|Dongzhimen Hospital Beijing
 August 16 2022 Phase 4

Chemical Information & Solubility

Molecular Weight 238.41 Formula

C16H30O
CAS No. 541-91-3 SDF Download Muscone SDF
Density 0.922 g/mL
Smiles CC1CCCCCCCCCCCCC(=O)C1
Storage (From the date of receipt) 2 years -80°C liquid

In vitro
Batch:

DMSO : 100 mg/mL ( (419.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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