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NLRP3

NLRP3 Products

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  • NLRP3 Inhibitors (17)
  • NLRP3 Activator (1)
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  • New NLRP3 Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7809 MCC950 Sodium MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Circ Res, 2024, 135(9):933-950
Int J Biol Sci, 2024, 20(9):3393-3411
Cell Death Dis, 2024, 15(5):360
S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Cell Death Dis, 2024, 15(1):43
Cell Prolif, 2024, e13720.
J Transl Med, 2024, 22(1):497
S6653 Nigericin sodium salt Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
Biomed Pharmacother, 2024, 174:116548
Biomed Pharmacother, 2024, 180:117512
J Anim Sci Biotechnol, 2024, 15(1):116
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
iScience, 2024, 27(3):109118
Antioxidants (Basel), 2023, 12(3)722
J Exp Clin Cancer Res, 2022, 41(1):74
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Chin Med J (Engl), 2022, 135(12):1474-1485
Biomed Res Int, 2022, 2022:7250578
Int Immunopharmacol, 2021, 92:107358
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
eprints, 2023, 10.14943/doctoral.k15475
Am J Pathol, 2022, S0002-9440(22)00076-1
Immunopharmacol Immunotoxicol, 2022, 1-24
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
iScience, 2023, 26(3):106089
iScience, 2023, 26(3):106089
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E0138 YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.
S3290 Procyanidin B2 (PCB2) Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
BMC Cardiovasc Disord, 2024, 24(1):231
S9899 BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
E1970New BAL-0028 BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
E3652 Rehmanniae radix praeparata Extract Rehmanniae radix praeparata Extract is extracted from Rehmanniae radix praeparata, which can improve diabetes through AMPK-mediated NF-κB/NLRP3 signaling pathway.
E4663New INF195 INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E3367 Garlic chives Extract Garlic chives Extract is extracted from Allium tuberosum, which provides a new therapeutic in the treatment of NLRP3 inflammasome-driven diseases.
E1281 Dimethyl itaconate Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
E1872New Selnoflast Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.
S9261 Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.
J Cardiothorac Surg, 2024, 19(1):435
E0225 Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
S7809 MCC950 Sodium MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Circ Res, 2024, 135(9):933-950
Int J Biol Sci, 2024, 20(9):3393-3411
Cell Death Dis, 2024, 15(5):360
S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Cell Death Dis, 2024, 15(1):43
Cell Prolif, 2024, e13720.
J Transl Med, 2024, 22(1):497
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
iScience, 2024, 27(3):109118
Antioxidants (Basel), 2023, 12(3)722
J Exp Clin Cancer Res, 2022, 41(1):74
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Chin Med J (Engl), 2022, 135(12):1474-1485
Biomed Res Int, 2022, 2022:7250578
Int Immunopharmacol, 2021, 92:107358
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
eprints, 2023, 10.14943/doctoral.k15475
Am J Pathol, 2022, S0002-9440(22)00076-1
Immunopharmacol Immunotoxicol, 2022, 1-24
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
iScience, 2023, 26(3):106089
iScience, 2023, 26(3):106089
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E0138 YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.
S3290 Procyanidin B2 (PCB2) Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
BMC Cardiovasc Disord, 2024, 24(1):231
E1970New BAL-0028 BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
E3652 Rehmanniae radix praeparata Extract Rehmanniae radix praeparata Extract is extracted from Rehmanniae radix praeparata, which can improve diabetes through AMPK-mediated NF-κB/NLRP3 signaling pathway.
E4663New INF195 INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E3367 Garlic chives Extract Garlic chives Extract is extracted from Allium tuberosum, which provides a new therapeutic in the treatment of NLRP3 inflammasome-driven diseases.
E1872New Selnoflast Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.
S9261 Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.
J Cardiothorac Surg, 2024, 19(1):435
E0225 Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
S6653 Nigericin sodium salt Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
Biomed Pharmacother, 2024, 174:116548
Biomed Pharmacother, 2024, 180:117512
J Anim Sci Biotechnol, 2024, 15(1):116
S9899 BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
E1970New BAL-0028 BAL-0028 (Compound 3), which belongs to the indazole class is an inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds tightly to the NACHT domain of NLRP3, with KD values ranging from 104 to 123 nM. BAL-0028 also exhibits anti-inflammatory activity.
E4663New INF195 INF 195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF 195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E1872New Selnoflast Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.

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Tags: NLRP3 inhibitor|NLRP3 agonist|NLRP3 activator|NLRP3 inducer|NLRP3 antagonist|NLRP3 signaling pathway|NLRP3 assay kit