Home Metabolism Liver X Receptor activator - SREBP inhibitor - NLRP3 activator Desmosterol For research use only.

Desmosterol

Desmosterol is the immediate unsaturated precursor of cholesterol and the final biosynthetic intermediate in the Bloch pathway and a key activator of liver X receptors(LXR) while inhibiting SREBP to regulate lipid homeostasis. Its reduction promotes mitochondrial ROS production in macrophages and activates the NLRP3 inflammasome exhibiting potential for research in inflammation, metabolism, and cardiovascular diseases.

Desmosterol Chemical Structure

Desmosterol Chemical Structure

CAS No. 313-04-2

Purity & Quality Control

Batch: E704101 Ethanol]20 mg/mL]false]DMSO]2 mg/mL]false]Water]Insoluble]false Purity: 97.97%
97.97

Desmosterol Related Products

Biological Activity

Description Desmosterol is the immediate unsaturated precursor of cholesterol and the final biosynthetic intermediate in the Bloch pathway and a key activator of liver X receptors(LXR) while inhibiting SREBP to regulate lipid homeostasis. Its reduction promotes mitochondrial ROS production in macrophages and activates the NLRP3 inflammasome exhibiting potential for research in inflammation, metabolism, and cardiovascular diseases.

Chemical Information & Solubility

Molecular Weight 384.64 Formula

C27H44O
CAS No. 313-04-2 SDF Download Desmosterol SDF
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 20 mg/mL

DMSO : 2 mg/mL ( (5.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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