Home Metabolism Liver X Receptor agonist SR9243 For research use only.

SR9243

SR9243 is a potent and selective LXR inverse agonist.

SR9243 Chemical Structure

SR9243 Chemical Structure

CAS No. 1613028-81-1

Purity & Quality Control

SR9243 Related Products

Biological Activity

Description SR9243 is a potent and selective LXR inverse agonist.
Targets
LXR [1]
In vitro
In vitro In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments. [1]
Cell Research Cell lines DU-145, SW620, HOP-62, PC3, HT-29, and NCI-H23 cancer cells
Concentrations 100 nM
Incubation Time 96 h
Method Cells are cultured in 96 well plates and treated with designated amounts of SR9243 for 96 hr in media containing 1% FBS and antibiotics. Cell-viability is assessed using the Cell-titre 96 kit according to the manufacturer’s guidelines. Cell culture media is supplemented with oleate, stearate and palmitate dissolved in methanol to a concentration of 25 mM. 25 mM stocks are then diluted 10 fold in PBS containing 0.9% BSA. Lipid stocks (100X) are stored at −20° until needed.
In Vivo
In vivo In Ob/Ob mice fed a high-fat diet, SR9243 (60 mg/kg, i.p.) inhibits LXR-dependent lipogenic enzyme gene expression and tumor growth. [1]
Animal Research Animal Models Mice bearing SW620, DU-145, or LLC tumors
Dosages 60 mg/kg, once daily
Administration i.p.

Chemical Information & Solubility

Molecular Weight 626.62 Formula

C31H32BrNO4S2
CAS No. 1613028-81-1 SDF Download SR9243 SDF
Smiles CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CCC2=CC(=CC=C2)Br)CC3=CC=C(C=C3)C4=CC(=CC=C4)S(=O)(=O)C)C
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 20 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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