Home Angiogenesis Bcr-Abl inhibitor - NF-κB inhibitor - Apoptosis related activator - CaMK modulator Berbamine For research use only.

Berbamine

Synonyms: BA, BBM

Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).

Berbamine Chemical Structure

Berbamine Chemical Structure

CAS No. 478-61-5

Purity & Quality Control

Berbamine Related Products

Signaling Pathway

Bcr-Abl Signaling Pathways

Bcr-Abl Signaling Pathway

Biological Activity

Description Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
Targets
Bcr-Abl [1] NF-κB [2] CaMKII [3]

Chemical Information & Solubility

Molecular Weight 608.72 Formula

C37H40N2O6
CAS No. 478-61-5 SDF --
Smiles CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
Storage (From the date of receipt) 3 years -20°C powder

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DMSO : 100 mg/mL ( (164.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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