Home Immunology & Inflammation Immunology & Inflammation related chemical Secoisolariciresinol diglucoside For research use only.

Secoisolariciresinol diglucoside

Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.

Secoisolariciresinol diglucoside Chemical Structure

Secoisolariciresinol diglucoside Chemical Structure

CAS No. 148244-82-0

Purity & Quality Control

Batch: S378001 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 99.43%
99.43

Secoisolariciresinol diglucoside Related Products

Biological Activity

Description Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
In vitro
In vitro Secoisolariciresinol diglucoside (SDG) inhibits colon cancer cell growth by inducing S-phase cell cycle arrest[1]. SDG is effective in mitigating iron-induced cellular damage and death. SDG is capable of preventing the increase in inflammation in iron treated cells[2].
In Vivo
In vivo Secoisolariciresinol diglucoside (SDG) has been shown to decrease the production of inflammatory mediators and reduce oxidative stress. Its treatment is also found to reduce the development of hypercholesterolemic atherosclerosis in rabbits fed a high cholesterol diet, and reduce the development of diabetes in rats. SDG prevents the development of hypercholesterolemic atherosclerosis, induces angiogenesis-mediated cardioprotection, and prevents the development of type 1 and type 2 diabetes. SDG may have a cardioprotective role in cardiac iron overload[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04816890 Completed
Type 1 Diabetes Mellitus
Adocia
 March 23 2021 Phase 2
NCT01234506 Completed
Oxidative Stress|Inflammation|Aging|Dementia|Pain
University of Saskatchewan|Saskatchewan Health Research Foundation
 October 2010 Phase 2

Chemical Information & Solubility

Molecular Weight 686.7 Formula

C32H46O16
CAS No. 148244-82-0 SDF Download Secoisolariciresinol diglucoside SDF
Smiles COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (145.62 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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