Home Immunology & Inflammation Immunology & Inflammation related chemical Picroside II For research use only.

Picroside II

Synonyms: 6-Vanilloylcatalpol, Vanilloyl catalpol

Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

Picroside II Chemical Structure

Picroside II Chemical Structure

CAS No. 39012-20-9

Purity & Quality Control

Batch: S376501 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.71%
99.71

Picroside II Related Products

Biological Activity

Description Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
In vitro
In vitro Picroside II can reduce H2O2-induced PC12 cell damage and improve cell survival[3]. Picroside II effectively attenuates fatty acid accumulation by decreasing FFAs uptake and lipogenesis. Picroside II also decreases the expression of gluconeogenic genes[4]. Picroside II significantly decreases the concentrations of TNF-α, IL-1β, and IL-6 in cells. It suppresses the activation of p65 NF-κB signaling pathway compared with LPS stimulation[5].
Cell Research Cell lines HepG2 cells
Concentrations 0-300 μM
Incubation Time 24 h
Method HepG2 cells are loaded with different concentrations of FFAs, picroside I, picroside II, and silibinin for 24 hours. Cytotoxicity is measured via MTT assay.
In Vivo
In vivo Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5[1]. In the HDM-induced asthmatic model, picroside II significantly reduces inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues[2].
Animal Research Animal Models adult male Wistar rats
Dosages 20 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 512.46 Formula

C23H28O13
CAS No. 39012-20-9 SDF Download Picroside II SDF
Smiles COC1=C(C=CC(=C1)C(=O)OC2C3C=COC(C3C4(C2O4)CO)OC5C(C(C(C(O5)CO)O)O)O)O
Storage (From the date of receipt)

In vitro
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In vivo
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