Home Immunology & Inflammation Immunology & Inflammation related chemical Loxoprofen For research use only.

Loxoprofen

Synonyms: Koloxo, Loxoprofene, Loxoprofeno

Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.

Loxoprofen Chemical Structure

Loxoprofen Chemical Structure

CAS No. 68767-14-6

Purity & Quality Control

Batch: S468201 DMSO]49 mg/mL]false]Ethanol]49 mg/mL]false]Water]Insoluble]false Purity: 99.81%
99.81

Loxoprofen Related Products

Biological Activity

Description Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
In vitro
In vitro Loxoprofen sodium(LOX) does not affect the proliferation and viability of LLC cells in vitro. HUVECs treated with LOX results in the inhibition of the tubular formation. Treatment with 50 mg/ml LOX reveals a 33% decline in in vitro angiogenesis, compared with vehicle-treated HUVECs. This inhibition is presumably due to inhibition of VEGF activity[1].
Cell Research Cell lines LLC cells
Concentrations 50 μg/ml
Incubation Time 0-6 days
Method

To determine the proliferation of LLC cells with or without Loxoprofen, 2×104 cells are seeded into 100-mm dishes containing 10 ml culture medium supplemented with 50 μg/ml Loxoprofen or vehicle on day 0. On days 2, 3, 4 and 6, the cells are trypsinized and counted.
In Vivo
In vivo Loxoprofen sodium (LOX), inhibits in vivo growth of implanted Lewis lung carcinoma (LLC). Intratumoral vessel density in LOX-treated mice is significantly lower than that of mice without treatment. Intratumoral expressions of vascular endothelial growth factor (VEGF) mRNA are attenuated by the LOX treatment. LOX suppresses both intratumoral and systemic VEGF protein in LLC-implanted mice. LOX also inhibits tubular formation of primary cultured human umbilical vein endothelial cells, presumably due to the inhibition of VEGF. In patients with advanced non-small cell lung cancer, LOX medication (120 mg/day) for a week significantly decreases the plasma VEGF level[1].
Animal Research Animal Models C57BL/6 and BDF1 mice
Dosages 60 μg/ml
Administration via drinking water
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00676117 Completed
Healthy
AstraZeneca
 April 2008 Phase 1

Chemical Information & Solubility

Molecular Weight 246.30 Formula

C15H18O3
CAS No. 68767-14-6 SDF Download Loxoprofen SDF
Smiles CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (198.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 49 mg/mL

Water : Insoluble


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In vivo
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