Home Immunology & Inflammation Immunology & Inflammation related chemical Ligustrazine hydrochloride For research use only.

Ligustrazine hydrochloride

Synonyms: Tetramethylpyrazine HCl, Tetrapyrazine HCl

Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

Ligustrazine hydrochloride Chemical Structure

Ligustrazine hydrochloride Chemical Structure

CAS No. 76494-51-4

Purity & Quality Control

Batch: S377501 DMSO]34 mg/mL]false]]]false]]]false Purity: 99.65%
99.65

Ligustrazine hydrochloride Related Products

Biological Activity

Description Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
In vitro
In vitro Tetramethylpyrazine (TMP) is described as "calcium antagonist" and produces a vasodilation effect via inhibiting Ca2+ influx and the release of intracellular Ca2+ at first. TMP can affect the calcium influx, at least partly, by mediating the opening of potassium channel. TMP is also reported to have a direct effect on L-type calcium current, since it can reduce calcium transient in a dose-dependent manner when applied to rabbit ventricular myocyte. TMP also exerts an endothelium protective property via downregulating the expression of ICAM-1 and HSP60. TMP can restrain LPS-induced IL-8 overexpression in HUVECs at both the protein and mRNA levels, which is possibly due to blocking the activation of the NF-kB-dependent pathway; the involvement of ERK and p38 MAPK signaling pathway has also been observed[1].
Cell Research Cell lines HL-60 cells
Concentrations 300 µg/mL
Incubation Time 24, 48, 60, 72 h
Method

Cell viability is determined by the MTT assay. HL-60 cells are treated with 300 µg/mL TMP, 0.5 µM As2O3, and 300 µg/mL TMP combined with 0.5 µM As2O3, respectively.
In Vivo
In vivo Tetramethylpyrazine (TMP) can stimulate NO production in pulmonary arteries of rat. Akt and the endothelial isoform of nitric oxide synthase (eNOS) phosphorylation were significantly upregulated after TMP pretreatment in vivo. TMP can suppress the proliferation of VSMC in rabbit aortic vascular. TMP can decrease the ANP mRNA expression in cardiomyocyte hypertrophy rat model and suppress the level of pJAK2, pJAK1, or pSTAT3, demonstrating that TMP can inhibit JAK-STAT signal transduction. It has a short in-vivo half-life (T1/2=2.89 h)[1].
Animal Research Animal Models A rat model of Parkinson
Dosages 20 mg/kg/d
Administration i.p.

Chemical Information & Solubility

Molecular Weight 172.66 Formula

C8H12N2.HCl
CAS No. 76494-51-4 SDF Download Ligustrazine hydrochloride SDF
Smiles CC1=C(N=C(C(=N1)C)C)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (196.91 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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