Home Immunology & Inflammation Immunology & Inflammation related agonist - RAR/RXR antagonist - GPR agonist Latanoprost For research use only.

Latanoprost

Synonyms: Xalatan, PhXA41, PHXA-41

Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

Latanoprost Chemical Structure

Latanoprost Chemical Structure

CAS No. 130209-82-4

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Latanoprost Related Products

Biological Activity

Description Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
Targets
retinoid X receptor α [2] PGF-prostanoid receptor [3]
In vitro
In vitro Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].
Cell Research Cell lines Human corneal stromal (HCS) cells
Concentrations from 50 mg/l to 0.78125 mg/l
Incubation Time 4, 8, 12 h
Method HCS cells were inoculated into a 24-well culture plate (Nunc) and cultured in 10% FBS-DMEM/F12 medium at 37°C in a humidified 5% CO2 incubator. After the cells grew into logarithmic phase, the culture medium of each culture plate well was replaced entirely with the medium containing latanoprost at concentrations varying from 50 mg/l to 0.78125 mg/l, respectively. The cells were cultured under the same condition as described earlier, and their morphology and growth status were monitored every 4 h under an Eclipse TS100 inverted microscope.
In Vivo
In vivo Latanoprost, a clinical drug for treating primary open-angle glaucoma and intraocular hypertension, effectively ameliorates glucose and lipid disorders in two mouse models of type 2 diabetes. Its treatment improves glucose tolerance. Chronic administration of latanoprost decreases serum lipids and enhances insulin signalling in white adipose tissue and skeletal muscle. It effectually activates AMPK and regulates glucose and lipid metabolism-relevant genes in diabetic mice[2].
Animal Research Animal Models db/db or ob/ob mice
Dosages 10 or 40 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05333419 Completed
Open Angle Glaucoma|Ocular Hypertension
PolyActiva Pty Ltd
 March 4 2022 Phase 1
NCT02622334 Completed
Glaucoma
Hoffmann-La Roche
 December 29 2015 Phase 1
NCT00941525 Completed
Open Angle Glaucoma|Ocular Hypertension
Aristotle University Of Thessaloniki
 September 2009 Phase 4

Chemical Information & Solubility

Molecular Weight 432.59 Formula

C26H40O5
CAS No. 130209-82-4 SDF Download Latanoprost SDF
Density 1.093 g/mL
Smiles CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Storage (From the date of receipt) 2 years -80°C liquid

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