Home Immunology & Inflammation Immunology & Inflammation related inhibitor Diammonium Glycyrrhizinate For research use only.

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.

Diammonium Glycyrrhizinate Chemical Structure

Diammonium Glycyrrhizinate Chemical Structure

CAS No. 79165-06-3

Purity & Quality Control

Diammonium Glycyrrhizinate Related Products

Biological Activity

Description Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
In Vivo
In vivo Intraperitoneal administration of DG protects mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells is significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 is improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way[1]. DG is able to reduce inflammatory injury via suppression of nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB), tumor necrosis factor‑α and intercellular adhesion molecule 1, which are thought to promote inflammatory injury. DG has neuroprotective potential against ischemia‑reperfusion injury in a model of focal cerebral ischemic‑reperfusion injury[2].
Animal Research Animal Models Sprague‑Dawley rats
Dosages 10 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06375772 Recruiting
Acute Nasopharyngitis
G.ST Antivirals GmbH
 April 2 2024 Phase 2
NCT05408091 Recruiting
Healthy Volunteers
Trellis Bioscience LLC|National Institute of Allergy and Infectious Diseases (NIAID)
 September 14 2023 Phase 1
NCT06030817 Recruiting
Malignant Tumor
Peking Union Medical College Hospital
 August 11 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 856.99 Formula

C42H62O16. 2H3N
CAS No. 79165-06-3 SDF Download Diammonium Glycyrrhizinate SDF
Smiles CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N.N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (116.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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