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Cortisone

Name: Cortisone
Brand: Selleck Chemicals
SKU: S5869
Rating: 5 (1 reviews)

Catalog No.S5869 Purity:99%

Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress. It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury.

Cortisone Chemical Structure

CAS No. 53-06-5

Purity & Quality Control

Batch: Purity: 99%

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Biological Activity

Description	Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress. It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04855630	Recruiting	Alzheimer Disease\|Dementia	University of Miami\|Shipley Foundation\|Dreem	March 1 2023	Not Applicable
NCT05790083	Active not recruiting	Atopic Dermatitis\|Eczema-Prone Skin	Bionorica SE	January 3 2023	Not Applicable
NCT05336968	Recruiting	Osteoarthritis Knee	United Health Services Hospitals Inc.	September 15 2022	Phase 4
NCT05435781	Recruiting	Adrenal Insufficiency\|Polymyalgia Rheumatica\|Giant Cell Arteritis	Ulla Feldt-Rasmussen\|Aarhus University Hospital\|Odense University Hospital\|Rigshospitalet Denmark	June 7 2022	Phase 4
NCT05237440	Recruiting	Obesity	University Hospital Limoges	April 13 2022	Not Applicable
NCT05222152	Active not recruiting	Primary Adrenal Insufficiency	Diurnal Limited	November 23 2021	Phase 2

Chemical Information & Solubility

Molecular Weight	360.44	Formula	C₂₁H₂₈O₅
CAS No.	53-06-5	SDF	--
Smiles	CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 72 mg/mL ( (199.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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