Home Immunology & Inflammation Immunology & Inflammation related chemical Citral For research use only.

Citral

Synonyms: Geranialdehyde

Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.

Citral Chemical Structure

Citral Chemical Structure

CAS No. 5392-40-5

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Citral Related Products

Biological Activity

Description Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.
In vitro
In vitro Citral is the mixture of two isomeric acyclic monoterpene aldehydes, the trans-isomer geranial or citral A and the cis-isomer neral or citral B. Several pharmacological activities of citral have been documented such as anti-inflammatory effects, antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi, and some protozoa, and anticancer activities against some cancer cell lines including leukemic, breast, and lymphoma cells. Treatment with citral results in an activation of caspase-3, leading to apoptosis in human U937, HL60, and NB4 and mouse RL12 and BS-24-1 leukemic cell lines. Moreover, it inhibits human breast cancer cell MCF-7 growth and induces cycle arrest in G2/M phase. Citral induces human lymphoma Ramos cell apoptosis by activating caspase activity in a concentration and time-dependent manner but has no effect on cell distribution in the cell cycle[1].
Cell Research Cell lines Ramos and PBMCs
Concentrations 10, 20, and 40 μM
Incubation Time 24 h
Method

Ramos and PBMCs (1 × 106 cells/ml) are also treated with doxorubicin in combination with citral (10, 20, and 40 µM) for 24 h at 37 °C. Cytotoxicity of treated cells is determined by adding 5 µl of 1 mg/ml resazurin solution in each well.
In Vivo
In vivo Citral can block the L-type calcium channels and shows a significant anti-inflammatory effect in the carrageenan model. It has a very important anti-inflammatory activity in the test of croton oil-induced ear edema in mice[2]. Treatment with citral oil in mice with lung injury induced by LPS inhibits TNF-α, IL-1β, and IL-6 levels both in vivo and in vitro[3].
Animal Research Animal Models Virgin female Wistar rats aged 7-9 weeks
Dosages 100-800 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 152.23 Formula

C10H16O
CAS No. 5392-40-5 SDF --
Density 0.888 g/mL at 25 °C
Smiles CC(=CCCC(=CC=O)C)C
Storage (From the date of receipt) 2 years -80°C liquid

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